Liquid-Based Cytology of Small Cell Carcinoma of the Cervix: A Multicenter Retrospective Study

IF 2.7 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

OncoTargets and therapy Pub Date : 2024-07-08 DOI:10.2147/ott.s460465

Yun Liu, Meirong Li, Yan Liu, Yu Wan, Bo Yang, Dan Li, Shaohua Wang

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引用次数: 0

Abstract

Background/Aims: There are currently few reports describing the liquid-based cytological characteristics of small cell neuroendocrine carcinoma of the cervix. This study aimed to retrospectively analyze these features to reduce missed or misdiagnosis.
Methods: A total of 11 patients with histologically diagnosed small cell carcinoma of the cervix from three hospitals between 2017 and 2023 were included in this study. The cytological morphology of small cell carcinoma of the cervix and causes of missed or misdiagnosis were analyzed and summarized through a review of clinical data, liquid-based cytology, histology, immunohistochemistry, and human papillomaviruses (HPV) test results.
Results: In this study, the positivity rate of preliminary cytological screening was 63.6% (7/11); however, no cases were accurately diagnosed as small cell carcinoma of the cervix. A total of 36.4% (4/11) of small cell carcinoma of the cervix cases were cytologically negative; retrospective cytology found that two of these were false negatives. The main cytological features of small cell carcinoma of the cervix were summarized. Most of the liquid-based cytology smear cells were dense, and almost all cases showed clustered and scattered cytoplasm-scanty tumor cells. The tumor cells were all deeply stained and relatively consistent small cells. Most cases showed typical nuclear molding, chromatin stippling, and no obvious nucleoli. Mild nuclear smears, nuclear fragments, and mitotic figures were seen in most cases.
Conclusion: Liquid-based cytology has a high rate of missed diagnosis and misdiagnosis in small cell carcinoma of the cervix. This study confirms that reviewing cytology results can effectively reduce this proportion and that increasing understanding of small cell carcinoma of the cervix morphology is conducive to improving the cytology-based diagnosis rate.

Keywords: cervical cytology, small cell carcinoma, cervical cancer, diagnostic rate, neuroendocrine

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宫颈小细胞癌的液基细胞学：一项多中心回顾性研究

背景/目的：目前很少有报告描述宫颈小细胞神经内分泌癌的液基细胞学特征。本研究旨在回顾性分析这些特征，以减少漏诊或误诊：本研究共纳入2017年至2023年间三家医院经组织学诊断为宫颈小细胞癌的11例患者。通过回顾性分析临床资料、液基细胞学、组织学、免疫组化以及人乳头瘤病毒（HPV）检测结果，分析总结宫颈小细胞癌的细胞学形态以及漏诊、误诊原因：本研究中，细胞学初步筛查的阳性率为 63.6%（7/11），但没有病例被准确诊断为宫颈小细胞癌。共有 36.4%（4/11）的宫颈小细胞癌细胞学结果为阴性；回顾性细胞学检查发现，其中两例为假阴性。总结了宫颈小细胞癌的主要细胞学特征。大多数液基细胞学涂片细胞致密，几乎所有病例都表现为簇状和散在的胞浆稀少的肿瘤细胞。肿瘤细胞均为深染且相对一致的小细胞。大多数病例表现为典型的核成型、染色质条纹状，无明显核仁。大多数病例可见轻度核涂片、核碎片和有丝分裂图形：结论：液基细胞学检查在宫颈小细胞癌中的漏诊率和误诊率很高。本研究证实，复查细胞学结果可有效降低这一比例，而且加深对宫颈小细胞癌形态学的了解有利于提高基于细胞学的诊断率。

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来源期刊

OncoTargets and therapy BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ONCOLOGY

CiteScore

9.70

自引率

0.00%

发文量

221

审稿时长

1 months

期刊介绍： OncoTargets and Therapy is an international, peer-reviewed journal focusing on molecular aspects of cancer research, that is, the molecular diagnosis of and targeted molecular or precision therapy for all types of cancer. The journal is characterized by the rapid reporting of high-quality original research, basic science, reviews and evaluations, expert opinion and commentary that shed novel insight on a cancer or cancer subtype. Specific topics covered by the journal include: -Novel therapeutic targets and innovative agents -Novel therapeutic regimens for improved benefit and/or decreased side effects -Early stage clinical trials Further considerations when submitting to OncoTargets and Therapy: -Studies containing in vivo animal model data will be considered favorably. -Tissue microarray analyses will not be considered except in cases where they are supported by comprehensive biological studies involving multiple cell lines. -Biomarker association studies will be considered only when validated by comprehensive in vitro data and analysis of human tissue samples. -Studies utilizing publicly available data (e.g. GWAS/TCGA/GEO etc.) should add to the body of knowledge about a specific disease or relevant phenotype and must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Bioinformatics studies must be validated using the authors’ own data through replication in an independent sample set and functional follow-up. -Single nucleotide polymorphism (SNP) studies will not be considered.