Benzylic C(sp3)–H fluorination

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2024-07-10 DOI:10.3762/bjoc.20.137

Alexander P. Atkins, Alice C. Dean, Alastair J. J. Lennox

引用次数: 0

Abstract

The selective fluorination of C(sp³)–H bonds is an attractive target, particularly for pharmaceutical and agrochemical applications. Consequently, over recent years much attention has been focused on C(sp³)–H fluorination, and several methods that are selective for benzylic C–H bonds have been reported. These protocols operate via several distinct mechanistic pathways and involve a variety of fluorine sources with distinct reactivity profiles. This review aims to give context to these transformations and strategies, highlighting the different tactics to achieve fluorination of benzylic C–H bonds.

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Beilstein J. Org. Chem. 2024, 20, 1527–1547. doi:10.3762/bjoc.20.137

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苄基 C（sp3）-H 氟化

摘要 C(sp3)–H 键的选择性氟化是一个极具吸引力的目标，尤其是在医药和农用化学品应用方面。因此，近些年来，C(sp3)–H 键的氟化作用备受关注，并已报道了几种对苄基 C–H 键具有选择性的方法。这些方法通过几种不同的机理途径进行操作，涉及具有不同反应性的各种氟源。本综述旨在介绍这些转化和策略的来龙去脉，重点介绍实现苄基 C–H 键氟化的不同策略。Chem.2024, 20, 1527–1547. doi:10.3762/bjoc.20.137

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

期刊介绍： The Beilstein Journal of Organic Chemistry is an international, peer-reviewed, Open Access journal. It provides a unique platform for rapid publication without any charges (free for author and reader) – Platinum Open Access. The content is freely accessible 365 days a year to any user worldwide. Articles are available online immediately upon publication and are publicly archived in all major repositories. In addition, it provides a platform for publishing thematic issues (theme-based collections of articles) on topical issues in organic chemistry. The journal publishes high quality research and reviews in all areas of organic chemistry, including organic synthesis, organic reactions, natural product chemistry, structural investigations, supramolecular chemistry and chemical biology.