Controlling Alzheimer’s disease by deep brain stimulation based on a data-driven cortical network model

IF 3.1 3区 工程技术 Q2 NEUROSCIENCES
SiLu Yan, XiaoLi Yang, ZhiXi Duan
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Abstract

This work aims to explore the control effect of DBS on Alzheimer's disease (AD) from a neurocomputational perspective. Firstly, a data-driven cortical network model is constructed using the Diffusion Tensor Imaging data. Then, a typical electrophysiological feature of EEG slowing in AD is reproduced by reducing the synaptic connectivity parameters. The corresponding changes in kinetic behavior mainly include an oscillation decrease in the amplitude and frequency of the pyramidal neuron population. Subsequently, DBS current with specific parameters is introduced into three potential targets of the hippocampus, the nucleus accumbens and the olfactory tubercle, respectively. The results indicate that applying DBS to simulated mild AD patients induces an increase in relative alpha power, a decrease in relative theta power, and a significant rightward shift of the dominant frequency. This is consistent with the EEG reversal in pharmacological treatments for AD. Further, the optimal stimulation strategy of DBS is investigated through spectral and statistical analyses. Specifically, the pathological symptoms of AD could be alleviated by adjusting the critical parameters of DBS, and the control effect of DBS on various targets is that the hippocampus is superior to the olfactory tubercle and nucleus accumbens. Finally, using correlation analysis between the power increments and the nodal degrees, it is concluded that the control effect of DBS is related to the importance of the nodes in the brain network. This study provides a theoretical guidance for determining DBS targets and parameters, which may have a substantial impact on the development of DBS treatment for AD.

Abstract Image

基于数据驱动的皮层网络模型,通过深部脑刺激控制阿尔茨海默病
这项研究旨在从神经计算的角度探讨 DBS 对阿尔茨海默病(AD)的控制效果。首先,利用弥散张量成像数据构建了一个数据驱动的皮层网络模型。然后,通过减少突触连接参数再现了 AD 脑电图变慢的典型电生理特征。动力学行为的相应变化主要包括锥体神经元群振幅和频率的振荡降低。随后,将具有特定参数的 DBS 电流分别引入海马、伏隔核和嗅结节三个潜在靶点。结果表明,对模拟的轻度注意力缺失症患者应用 DBS 会诱导相对 alpha 功率的增加、相对 theta 功率的减少以及主导频率的显著右移。这与药物治疗 AD 时的脑电图逆转一致。此外,还通过频谱和统计分析研究了 DBS 的最佳刺激策略。具体来说,通过调整 DBS 的关键参数可以缓解 AD 的病理症状,而 DBS 对不同靶点的控制效果是海马优于嗅结节和伏隔核。最后,利用功率增量与节点度之间的相关性分析,得出 DBS 的控制效果与大脑网络中节点的重要性有关的结论。该研究为确定DBS靶点和参数提供了理论指导,可能对DBS治疗AD的发展产生重大影响。
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来源期刊
Cognitive Neurodynamics
Cognitive Neurodynamics 医学-神经科学
CiteScore
6.90
自引率
18.90%
发文量
140
审稿时长
12 months
期刊介绍: Cognitive Neurodynamics provides a unique forum of communication and cooperation for scientists and engineers working in the field of cognitive neurodynamics, intelligent science and applications, bridging the gap between theory and application, without any preference for pure theoretical, experimental or computational models. The emphasis is to publish original models of cognitive neurodynamics, novel computational theories and experimental results. In particular, intelligent science inspired by cognitive neuroscience and neurodynamics is also very welcome. The scope of Cognitive Neurodynamics covers cognitive neuroscience, neural computation based on dynamics, computer science, intelligent science as well as their interdisciplinary applications in the natural and engineering sciences. Papers that are appropriate for non-specialist readers are encouraged. 1. There is no page limit for manuscripts submitted to Cognitive Neurodynamics. Research papers should clearly represent an important advance of especially broad interest to researchers and technologists in neuroscience, biophysics, BCI, neural computer and intelligent robotics. 2. Cognitive Neurodynamics also welcomes brief communications: short papers reporting results that are of genuinely broad interest but that for one reason and another do not make a sufficiently complete story to justify a full article publication. Brief Communications should consist of approximately four manuscript pages. 3. Cognitive Neurodynamics publishes review articles in which a specific field is reviewed through an exhaustive literature survey. There are no restrictions on the number of pages. Review articles are usually invited, but submitted reviews will also be considered.
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