Microbiota alert: Proteobacteria consume arginine to dampen omental antitumor immunity

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2024-07-10 DOI:10.1016/j.chom.2024.05.020

Xian Du, Zuliang Jie, Qiang Zou

引用次数: 0

Abstract

The microbiota can impact antitumor immunity, but whether the microbiota regulates omental antitumor immunity remains elusive. In this issue of Cell Host & Microbe, Meza-Perez et al. demonstrated that Proteobacteria consume arginine to increase Treg cell suppressive capacity and inhibit antitumor immune responses, promoting tumor growth in the omentum.

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微生物群警报：蛋白细菌消耗精氨酸抑制网膜抗肿瘤免疫力

微生物群可影响抗肿瘤免疫，但微生物群是否能调节网膜抗肿瘤免疫仍是未知数。在本期《细胞、宿主与amp; 微生物》（Cell Host & Microbe）杂志上，Meza-Perez 等人证实，蛋白细菌消耗精氨酸可增加 Treg 细胞抑制能力，抑制抗肿瘤免疫反应，促进网膜中肿瘤的生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.