Progress in the Application of Hydrogels in Intervertebral Disc Repair: A Comprehensive Review.

IF 3.2 2区医学 Q2 CLINICAL NEUROLOGY

Current Pain and Headache Reports Pub Date : 2024-07-10 DOI:10.1007/s11916-024-01296-6

Xin Chen, Shaoze Jing, Chenhui Xue, Xiaoming Guan

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Abstract

Purpose of review: Intervertebral disc degeneration (IVDD) is a common orthopaedic disease and an important cause of lower back pain, which seriously affects the work and life of patients and causes a large economic burden to society. The traditional treatment of IVDD mainly involves early pain relief and late surgical intervention, but it cannot reverse the pathological course of IVDD. Current studies suggest that IVDD is related to the imbalance between the anabolic and catabolic functions of the extracellular matrix (ECM). Anti-inflammatory drugs, bioactive substances, and stem cells have all been shown to improve ECM, but traditional injection methods face short half-life and leakage problems.

Recent findings: The good biocompatibility and slow-release function of polymer hydrogels are being noticed and explored to combine with drugs or bioactive substances to treat IVDD. This paper introduces the pathophysiological mechanism of IVDD, and discusses the advantages, disadvantages and development prospects of hydrogels for the treatment of IVDD, so as to provide guidance for future breakthroughs in the treatment of IVDD.

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水凝胶在椎间盘修复中的应用进展：全面回顾。

综述目的：椎间盘退变（IVDD）是一种常见的骨科疾病，也是导致腰背痛的重要原因，严重影响患者的工作和生活，给社会造成较大的经济负担。传统的 IVDD 治疗方法主要是早期止痛和晚期手术治疗，但无法逆转 IVDD 的病理进程。目前的研究表明，IVDD 与细胞外基质（ECM）的合成代谢功能失衡有关。抗炎药物、生物活性物质和干细胞都被证明可以改善 ECM，但传统的注射方法面临着半衰期短和渗漏的问题：高分子水凝胶具有良好的生物相容性和缓释功能，与药物或生物活性物质结合治疗 IVDD 正受到关注和探索。本文介绍了 IVDD 的病理生理机制，探讨了水凝胶治疗 IVDD 的优缺点和发展前景，以期为未来 IVDD 治疗的突破提供指导。

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来源期刊

Current Pain and Headache Reports CLINICAL NEUROLOGY-

CiteScore

6.10

自引率

2.70%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal aims to review the most important, recently published clinical findings regarding the diagnosis, treatment, and management of pain and headache. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of pain and headache. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as anesthetic techniques in pain management, cluster headache, neuropathic pain, and migraine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.