Changes in serum lipids following consumption of coconut oil and palm olein oil: A sequential feeding crossover clinical trial

IF 4.3 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes & Metabolic Syndrome-Clinical Research & Reviews Pub Date : 2024-06-01 DOI:10.1016/j.dsx.2024.103070

Hasinthi Swarnamali , Priyanga Ranasinghe , Ranil Jayawardena

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引用次数: 0

Abstract

Background

High incidence of cardiovascular disease (CVD) in South Asia is linked to genetic predisposition and diets high in saturated fatty acids (SFAs). Increased CVD prevalence correlates with rising palm oil consumption in some South Asian countries, where coconut oil and palm olein oil are primary SFA sources.

Objective

Compare the effects of coconut oil and palm olein oil on serum lipoprotein lipids and biochemical parameters in healthy adults.

Methods

A sequential feeding crossover clinical trial with two feeding periods of 8 weeks each was conducted among 40 healthy adults. Participants were provided palm olein oil in the first feeding period followed by coconut oil with a 16-week washout period in between. The outcomes measured were the difference in serum low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C), TC/HDL-C ratio, triglycerides (TG), very-low-density lipoprotein cholesterol (VLDL-C), fasting plasma glucose (FPG), and liver enzymes.

Results

Thirty-seven participants completed the study. LDL-C decreased by 13.0 % with palm olein oil (p < 0.001) and increased by 5.6 % with coconut oil (p = 0.044), showing a significant difference (p < 0.001). TC decreased by 9.9 % with palm olein oil (p < 0.001) and increased by 4.0 % with coconut oil (p = 0.044).

Conclusion

Palm olein oil consumption resulted in more favorable changes in lipid-related CVD risk factors (TC, LDL-C, TC:HDL-C, and FPG) compared to coconut oil.

Clinical Trial Registry number and website where it was obtained: (SLCTR/2019/034); https://slctr.lk/trials/slctr-2019-034.

查看原文本刊更多论文

食用椰子油和棕榈油后血清脂质的变化：连续喂食交叉临床试验。

背景：南亚地区心血管疾病（CVD）的高发病率与遗传易感性和高饱和脂肪酸（SFA）饮食有关。在一些南亚国家，椰子油和棕榈油是主要的饱和脂肪酸来源，心血管疾病发病率的增加与棕榈油消费量的增加有关：比较椰子油和棕榈油对健康成年人血清脂蛋白脂质和生化指标的影响：方法：在 40 名健康成年人中开展了一项连续喂养交叉临床试验，两次喂养期各为 8 周。参与者在第一个喂食期食用棕榈油，随后食用椰子油，中间有 16 周的清洗期。测量的结果是血清低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）和高密度脂蛋白胆固醇（HDL-C）、TC/HDL-C 比率、甘油三酯（TG）、极低密度脂蛋白胆固醇（VLDL-C）、空腹血浆葡萄糖（FPG）和肝酶的差异：37 名参与者完成了研究。食用棕榈油后，低密度脂蛋白胆固醇降低了 13.0%（p 结论：食用棕榈油后，低密度脂蛋白胆固醇降低了 13.0%：与椰子油相比，食用棕榈油可使与血脂相关的心血管疾病风险因素（血脂指数、低密度脂蛋白胆固醇、血脂指数：高密度脂蛋白胆固醇和血脂指数）发生更有利的变化。临床试验注册号和获取网站：（SLCTR/2019/034）；https://slctr.lk/trials/slctr-2019-034。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes & Metabolic Syndrome-Clinical Research & Reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

22.90

自引率

2.00%

发文量

248

审稿时长

51 days

期刊介绍： Diabetes and Metabolic Syndrome: Clinical Research and Reviews is the official journal of DiabetesIndia. It aims to provide a global platform for healthcare professionals, diabetes educators, and other stakeholders to submit their research on diabetes care. Types of Publications: Diabetes and Metabolic Syndrome: Clinical Research and Reviews publishes peer-reviewed original articles, reviews, short communications, case reports, letters to the Editor, and expert comments. Reviews and mini-reviews are particularly welcomed for areas within endocrinology undergoing rapid changes.