High-resolution and highly accelerated MRI T2 mapping as a tool to characterise renal tumour subtypes and grades.

IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Ines Horvat-Menih, Hao Li, Andrew N Priest, Shaohang Li, Andrew B Gill, Iosif A Mendichovszky, Susan T Francis, Anne Y Warren, Brent O'Carrigan, Sarah J Welsh, James O Jones, Antony C P Riddick, James N Armitage, Thomas J Mitchell, Grant D Stewart, Ferdia A Gallagher
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引用次数: 0

Abstract

Background: Clinical imaging tools to probe aggressiveness of renal masses are lacking, and T2-weighted imaging as an integral part of magnetic resonance imaging protocol only provides qualitative information. We developed high-resolution and accelerated T2 mapping methods based on echo merging and using k-t undersampling and reduced flip angles (TEMPURA) and tested their potential to quantify differences between renal tumour subtypes and grades.

Methods: Twenty-four patients with treatment-naïve renal tumours were imaged: seven renal oncocytomas (RO); one eosinophilic/oncocytic renal cell carcinoma; two chromophobe RCCs (chRCC); three papillary RCCs (pRCC); and twelve clear cell RCCs (ccRCC). Median, kurtosis, and skewness of T2 were quantified in tumours and in the normal-adjacent kidney cortex and were compared across renal tumour subtypes and between ccRCC grades.

Results: High-resolution TEMPURA depicted the tumour structure at improved resolution compared to conventional T2-weighted imaging. The lowest median T2 values were present in pRCC (high-resolution, 51 ms; accelerated, 45 ms), which was significantly lower than RO (high-resolution; accelerated, p = 0.012) and ccRCC (high-resolution, p = 0.019; accelerated, p = 0.008). ROs showed the lowest kurtosis (high-resolution, 3.4; accelerated, 4.0), suggestive of low intratumoural heterogeneity. Lower T2 values were observed in higher compared to lower grade ccRCCs (grades 2, 3 and 4 on high-resolution, 209 ms, 151 ms, and 106 ms; on accelerated, 172 ms, 160 ms, and 102 ms, respectively), with accelerated TEMPURA showing statistical significance in comparison (p = 0.037).

Conclusions: Both high-resolution and accelerated TEMPURA showed marked potential to quantify differences across renal tumour subtypes and between ccRCC grades.

Trial registration: ClinicalTrials.gov, NCT03741426 . Registered on 13 November 2018.

Relevance statement: The newly developed T2 mapping methods have improved resolution, shorter acquisition times, and promising quantifiable readouts to characterise incidental renal masses.

Abstract Image

高分辨率和高度加速的磁共振成像 T2 图是描述肾脏肿瘤亚型和分级的工具。
背景:目前还缺乏探查肾脏肿块侵袭性的临床成像工具,T2加权成像作为磁共振成像方案中不可或缺的一部分,只能提供定性信息。我们开发了基于回波合并、使用 k-t 欠采样和减小翻转角度(TEMPURA)的高分辨率加速 T2 映射方法,并测试了其量化肾脏肿瘤亚型和分级差异的潜力:对24例未接受过治疗的肾肿瘤患者进行了成像:7例肾肿瘤细胞瘤(RO)、1例嗜酸性/单核细胞肾细胞癌、2例嗜铬性RCC(chRCC)、3例乳头状RCC(pRCC)和12例透明细胞RCC(ccRCC)。对肿瘤和正常邻近肾皮质的 T2 中位数、峰度和偏度进行了量化,并对不同肾肿瘤亚型和不同级别的 ccRCC 进行了比较:与传统的 T2 加权成像相比,高分辨率 TEMPURA 能以更高的分辨率显示肿瘤结构。中位 T2 值最低的是 pRCC(高分辨率,51 毫秒;加速成像,45 毫秒),明显低于 RO(高分辨率;加速成像,p = 0.012)和 ccRCC(高分辨率,p = 0.019;加速成像,p = 0.008)。RO的峰度最低(高分辨率,3.4;加速度,4.0),表明瘤内异质性较低。与低级别ccRCC相比,高级别ccRCC的T2值更低(2、3和4级在高分辨率下分别为209毫秒、151毫秒和106毫秒;在加速TEMPURA下分别为172毫秒、160毫秒和102毫秒),加速TEMPURA与之相比具有统计学意义(p = 0.037):结论:高分辨率和加速 TEMPURA 在量化肾脏肿瘤亚型和 ccRCC 分级之间的差异方面都显示出明显的潜力:ClinicalTrials.gov, NCT03741426 .注册时间:2018年11月13日.相关性声明:新开发的T2映射方法具有更高的分辨率、更短的采集时间和有前景的可量化读数,可用于描述附带肾肿块的特征。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European Radiology Experimental
European Radiology Experimental Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
6.70
自引率
2.60%
发文量
56
审稿时长
18 weeks
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