Ying Wang, Jun Wang, Wang Lv, Hu Chen, Qian Yang, Yang Zhang, Run Guo, Xiao-Li Ma, Qian-Yu Zhang
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引用次数: 0
Abstract
Background: The diagnosis and treatment of depression in patients with chronic heart failure (CHF) is challenging, with no ideal treatment at present.
Aim: To analyze the clinical intervention effect of Xuefu Zhuyu decoction (XFZYD) on CHF complicated with depression.
Methods: The study cohort comprised 116 patients with CHF complicated with depression who received treatment from July 2020 to July 2023, of which 55 received Western medicine (control group) and 61 received XFZYD (research group). Data on clinical effectiveness, traditional Chinese medicine (TCM) syndrome score, cardiac function, negative emotions, and serum inflammatory factors, were collected for comparative analyses.
Results: Compared with the control group, the research group had an evidently higher total effective rate. Furthermore, there were marked reductions in TCM symptom score, left ventricular end-diastolic diameter, left ventricular end-systolic diameter, Self-Rating Depression Scale, Hamilton Depression Scale, high-sensitivity C-reactive protein, monocyte chemoattractant protein-1, and matrix metalloproteinase-9 in the research group after treatment, and these were lower than the corresponding values in the control group. Left ventricular ejection fraction was increased and higher in the research group compared with the control group after treatment.
Conclusion: Our findings conclusively proved that XFZYD was considerably superior to Western medicine for treating CHF complicated with depression because it significantly alleviated patients' symptoms, improved cardiac function, relieved negative emotions, and reduced the levels of serum inflammatory factors.
背景:目的:分析学府指南汤(XFZYD)对慢性心力衰竭并发抑郁症的临床干预效果。方法:研究对象为2020年7月至2023年7月接受治疗的116例慢性心力衰竭并发抑郁症患者,其中55例接受西药治疗(对照组),61例接受XFZYD治疗(研究组):研究队列包括在2020年7月至2023年7月期间接受治疗的116例CHF并发抑郁症患者,其中55例接受西药治疗(对照组),61例接受XFZYD治疗(研究组)。收集临床疗效、中医证候评分、心功能、负性情绪、血清炎症因子等数据进行对比分析:结果:与对照组相比,研究组的总有效率明显更高。此外,研究组治疗后中医症状评分、左室舒张末期内径、左室收缩末期内径、抑郁自评量表、汉密尔顿抑郁量表、高敏 C 反应蛋白、单核细胞趋化蛋白-1、基质金属蛋白酶-9 均明显下降,且均低于对照组的相应值。研究组治疗后的左心室射血分数增加,且高于对照组:我们的研究结果最终证明,在治疗合并抑郁症的慢性心力衰竭方面,XFZYD明显优于西药,因为它能显著减轻患者的症状,改善心脏功能,缓解负面情绪,降低血清炎症因子的水平。