Infrared thermogram image guided discontinuous appearances of hyaluronic acid for classification of arthritic knee joints

IF 2.9 2区 生物学 Q2 BIOLOGY
Puja Das , Satyabrata Nath , Ranjan Gupta , Sourav Dey Roy , Mrinal Kanti Bhowmik
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Abstract

The liveliness of a human potentially depends on his/her smooth movability. To accomplish the work of daily life, the joints of the body need to be healthy. However, the occurrence of Rheumatoid arthritis and Osteoarthritis has a significant prevalence towards the immovability of humankind. Rheumatoid arthritis (RA) and Osteoarthritis (OA) mostly affect the joints of the hand and knee which result in lifelong pain, inability to climb, walk, etc. In the early stages, these diseases attack the synovial membrane and synovial fluid, and further it destroys the soft tissues and bone structure. By early diagnosis, we can start the treatment in the early stage which may cure these diseases with such extreme consequences. As per clinical studies of previous literature, it is observed that synovial fluid imbalance appears in the early stage of such diseases and Hyaluronic Acid (HA) concentration also decreases for that. Therefore, estimation of HA is a significant key to arthritis disease classification and grading. In this paper, we proposed a hybrid framework for classification of arthritic knee joints based on the analysis of the discontinuous appearances of the HA concentration using infrared imaging technology. To meet up the specific necessities, firstly we have proposed a modified K-Means clustering algorithm for extraction of the region of interest (ROI) i.e., the knee joint surface. Secondly, a mathematical formulation is proposed to calculate the concentration of HA from the segmented ROIs. This experimental process was implemented on the publicly available IR (Infrared) Knee Joint Dataset and for further evaluation of the novelty of mathematical formulation, we have extended the proposed work to the classification of healthy and arthritis affected knee joints depending on significant discriminative characteristics of the HA concentration with respect to the existing significant imaging features. Experimental results and analysis demonstrates that concentration of HA has the dominant potential for classifying healthy and arthritic knee joints using infrared holistic images. Our experimental analysis reveals that estimation and combination of the HA concentration features with conventional handcrafted and deep features increases the classification performance with an average accuracy of 91% and 97.22% respectively as compared to the each individual feature sets.

红外热图图像引导下的透明质酸不连续外观用于膝关节关节炎的分类。
人的活力取决于其活动是否顺畅。要完成日常生活中的工作,身体的关节必须保持健康。然而,类风湿性关节炎和骨关节炎的发生严重影响了人类的活动能力。类风湿性关节炎(RA)和骨关节炎(OA)主要影响手关节和膝关节,导致终生疼痛、无法攀爬、行走等。在早期阶段,这些疾病会侵袭滑膜和滑液,并进一步破坏软组织和骨骼结构。通过早期诊断,我们可以在早期开始治疗,从而治愈这些具有极端后果的疾病。根据以往文献的临床研究,滑液失衡出现在此类疾病的早期阶段,透明质酸(HA)浓度也会因此而降低。因此,HA 的估算是关节炎疾病分类和分级的重要关键。在本文中,我们利用红外成像技术,基于对 HA 浓度不连续表现的分析,提出了一种用于膝关节炎分类的混合框架。为满足特定需求,我们首先提出了一种改进的 K-Means 聚类算法,用于提取感兴趣区域(ROI),即膝关节表面。其次,我们提出了一种数学公式,用于计算分段 ROI 中的 HA 浓度。为了进一步评估数学公式的新颖性,我们将提议的工作扩展到健康膝关节和关节炎膝关节的分类,这取决于 HA 浓度相对于现有重要成像特征的显著鉴别特征。实验结果和分析表明,HA 浓度在利用红外整体图像对健康膝关节和关节炎膝关节进行分类方面具有主导潜力。我们的实验分析表明,HA 浓度特征与传统手工特征和深度特征的估计和组合提高了分类性能,与每个单独特征集相比,平均准确率分别为 91% 和 97.22%。
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来源期刊
Journal of thermal biology
Journal of thermal biology 生物-动物学
CiteScore
5.30
自引率
7.40%
发文量
196
审稿时长
14.5 weeks
期刊介绍: The Journal of Thermal Biology publishes articles that advance our knowledge on the ways and mechanisms through which temperature affects man and animals. This includes studies of their responses to these effects and on the ecological consequences. Directly relevant to this theme are: • The mechanisms of thermal limitation, heat and cold injury, and the resistance of organisms to extremes of temperature • The mechanisms involved in acclimation, acclimatization and evolutionary adaptation to temperature • Mechanisms underlying the patterns of hibernation, torpor, dormancy, aestivation and diapause • Effects of temperature on reproduction and development, growth, ageing and life-span • Studies on modelling heat transfer between organisms and their environment • The contributions of temperature to effects of climate change on animal species and man • Studies of conservation biology and physiology related to temperature • Behavioural and physiological regulation of body temperature including its pathophysiology and fever • Medical applications of hypo- and hyperthermia Article types: • Original articles • Review articles
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