Cutting Edge: Redundant Roles for MHC Class II-, CD1d-, and MR1-restricted T Cells in Clearing Bartonella Infection.

IF 3.6 3区 医学 Q2 IMMUNOLOGY
Lena K Siewert, Katja Fromm, Christoph Dehio, Daniel D Pinschewer
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引用次数: 0

Abstract

The importance of unconventional T cells for mucosal immunity is firmly established but for systemic bacterial infection remains less well defined. In this study, we explored the role of various T cell subsets in murine Bartonella infection, which establishes persistent bacteremia unless controlled by antibacterial Abs. We found that αβ T cells are essential for Ab production against and clearance of B. taylorii, whereas MHC class I (MHC-I)- or MHC class II (MHC-II)-deficient mice eliminated B. taylorii infection with normal kinetics. Similarly, animals lacking either CD1d or MR1 suppressed bacteremia with normal kinetics. Interestingly, mice with a combined deficiency of either MHC-II and CD1d or MHC-II and MR1 failed to clear the infection, indicating that the combination of CD1d- and MR1-restricted T cells can compensate for the lack of MHC-II in this model. Our data document a previously underappreciated contribution of unconventional T cells to the control of systemic bacterial infection, supposedly as helper cells for antibacterial Ab production.

前沿:MHC II 类、CD1d 和 MR1 限制性 T 细胞在清除巴顿氏菌感染中的冗余作用。
非常规 T 细胞对粘膜免疫的重要性已得到证实,但对全身性细菌感染的重要性还没有得到很好的界定。在本研究中,我们探讨了各种 T 细胞亚群在小鼠巴顿氏菌感染中的作用,巴顿氏菌感染会导致持续性菌血症,除非使用抗菌素 Abs 控制感染。我们发现,αβ T 细胞对于抗泰勒氏杆菌抗体的产生和清除至关重要,而 MHC I 类(MHC-I)或 MHC II 类(MHC-II)缺陷小鼠能以正常的动力学消除泰勒氏杆菌感染。同样,缺乏 CD1d 或 MR1 的动物也能以正常动力学抑制菌血症。有趣的是,同时缺乏 MHC-II 和 CD1d 或 MHC-II 和 MR1 的小鼠无法清除感染,这表明 CD1d 和 MR1 限制性 T 细胞的组合可以弥补该模型中 MHC-II 的缺乏。我们的数据证明了非常规 T 细胞对控制全身性细菌感染的贡献,这种贡献以前未得到重视,据说它是抗菌 Ab 生成的辅助细胞。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of immunology
Journal of immunology 医学-免疫学
CiteScore
8.20
自引率
2.30%
发文量
495
审稿时长
1 months
期刊介绍: The JI publishes novel, peer-reviewed findings in all areas of experimental immunology, including innate and adaptive immunity, inflammation, host defense, clinical immunology, autoimmunity and more. Special sections include Cutting Edge articles, Brief Reviews and Pillars of Immunology. The JI is published by The American Association of Immunologists (AAI)
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