The Efficacy of the Herbal Formula of Bunium persicum and Coriandrum sativum on Clinical Symptoms of Patients with Functional Dyspepsia: A Double-Blind Randomized Controlled Trial.

IF 1.1 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE
Complementary Medicine Research Pub Date : 2024-01-01 Epub Date: 2024-07-17 DOI:10.1159/000539472
Maryam Azimi, Mahboobeh Esfandiarpour, Mahboobeh Raeiszadeh, Faranak Salajegheh, Ali Saeidpour Parizi
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Abstract

Introduction: Functional dyspepsia (FD) is one of the most prevalent chronic disorders affecting up to 30% of the world population with considerable impairment of quality of life. This study evaluated the efficacy of the herbal preparation of Bunium persicum (Boiss.) B.Fedtsch. and Coriandrum sativum L. on symptom severity, symptom frequency, and quality of life of patients with FD.

Methods: This double-blind randomized controlled clinical trial, with parallel groups allocation ratio of 1:1, was conducted in a referral clinic of Afzalipour Hospital affiliated with Kerman University of Medical Sciences in Kerman, southeastern Iran. A total of 90 patients with FD (diagnosed based on the Rome IV criteria) were included in this study. The patients with complications during the intervention, pregnancy or lactation, a history of allergy to herbal drugs, use of other medication that affect the symptoms of FD during the study, and severe organic or psychiatric disorders were excluded. The participants received one capsule containing 500 mg of herbal preparation or placebo twice a day for 4 weeks and were subsequently followed up for 4 more weeks. Clinical outcomes were assessed via the Dyspepsia Severity Questionnaire, the Rome IV Diagnostic Questionnaire, and Nepean Dyspepsia Index Questionnaire.

Results: A total 40 participants in each group completed the follow-up period, and their data were analyzed statistically. All clinical outcomes showed significant improvements by herbal preparation compared to the placebo without serious side effects (p < 0.05).

Conclusions: This herbal preparation can significantly improve the quality of life, and symptoms of FD compared to placebo.

杜仲和芫荽中药配方对功能性消化不良患者临床症状的疗效:一项双盲随机主动对照试验。
简介功能性消化不良(FD)是最普遍的慢性疾病之一,影响着全球多达 30% 的人口,严重损害了他们的生活质量。本研究评估了Bunium persicum (Boiss.) B.Fedtsch.和 Coriandrum Sativum L.草药配方对功能性消化不良患者症状严重程度、症状频率和生活质量的疗效:这项双盲随机对照临床试验在伊朗东南部克尔曼市的克尔曼医科大学附属阿夫扎利布尔医院转诊诊所进行,平行分组分配比例为 1:1。本研究共纳入了 90 名 FD 患者(根据罗马 IV 标准诊断)。排除了在干预期间出现并发症、怀孕或哺乳期、对草药有过敏史、在研究期间使用其他会影响 FD 症状的药物以及严重器质性或精神性疾病的患者。参与者每天两次服用含有 500 毫克草药配方或安慰剂的胶囊,每次一粒,连续服用 4 周,随后再随访 4 周。临床结果通过消化不良严重程度问卷、罗马IV诊断问卷和Nepean消化不良指数问卷进行评估:每组共有 40 名参与者完成了随访,并对他们的数据进行了统计分析。与安慰剂相比,中药配方的所有临床结果均有明显改善,且无严重副作用(P <0.05):结论:与安慰剂相比,该草药配方能明显改善 FD 的生活质量和症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Complementary Medicine Research
Complementary Medicine Research Medicine-Complementary and Alternative Medicine
CiteScore
2.90
自引率
5.60%
发文量
50
期刊介绍: Aims and Scope ''Complementary Medicine Research'' is an international journal that aims to bridge the gap between conventional medicine and complementary/alternative medicine (CAM) on a sound scientific basis, promoting their mutual integration. Accordingly, experts of both conventional medicine and CAM medicine cooperate on the journal‘s editorial board, which accepts papers only after a rigorous peer-review process in order to maintain a high standard of scientific quality. Spectrum of ''Complementary Medicine Research'': - Review and Original Articles, Case Reports and Essays regarding complementary practice and methods - Journal Club: Analysis and discussion of internationally published articles in complementary medicine - Editorials of leading experts in complementary medicine - Questions of complementary patient-centered care - Education in complementary medicine - Reports on important meetings and conferences - Society Bulletins of Schweizerische Medizinische Gesellschaft für Phytotherapie (SMGP) and Deutsche Gesellschaft für Naturheilkunde Bibliographic Details Complementary Medicine Research Journal Abbreviation: Complement Med Res ISSN: 2504-2092 (Print) e-ISSN: 2504-2106 (Online) DOI: 10.1159/issn.2504-2092 www.karger.com/CMR
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