A computational study of the influence of thyroarytenoid and cricothyroid muscle interaction on vocal fold dynamics in an MRI-based human laryngeal model

IF 3 3区医学 Q2 BIOPHYSICS

Biomechanics and Modeling in Mechanobiology Pub Date : 2024-07-09 DOI:10.1007/s10237-024-01869-9

Weili Jiang, Biao Geng, Xudong Zheng, Qian Xue

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Abstract

A human laryngeal model, incorporating all the cartilages and the intrinsic muscles, was reconstructed based on MRI data. The vocal fold was represented as a multilayer structure with detailed inner components. The activation levels of the thyroarytenoid (TA) and cricothyroid (CT) muscles were systematically varied from zero to full activation allowing for the analysis of their interaction and influence on vocal fold dynamics and glottal flow. The finite element method was employed to calculate the vocal fold dynamics, while the one-dimensional Bernoulli equation was utilized to calculate the glottal flow. The analysis was focused on the muscle influence on the fundamental frequency (f_o). We found that while CT and TA activation increased the f_o in most of the conditions, TA activation resulted in a frequency drop when it was moderately activated. We show that this frequency drop was associated with the sudden increase of the vertical motion when the vibration transited from involving the whole tissue to mainly in the cover layer. The transition of the vibration pattern was caused by the increased body-cover stiffness ratio that resulted from TA activation.

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基于核磁共振成像的人喉模型中甲状腺和环甲肌相互作用对声带动力学影响的计算研究。

根据核磁共振成像数据重建了包含所有软骨和固有肌肉的人类喉部模型。声带被表示为具有详细内部组件的多层结构。甲状舌骨肌（TA）和环甲肌（CT）的激活水平从零到完全激活有系统地变化，以便分析它们之间的相互作用以及对声带动力学和声门流动的影响。计算声带动力学时采用了有限元方法，而计算声门流量时则采用了一维伯努利方程。分析的重点是肌肉对基频（fo）的影响。我们发现，虽然 CT 和 TA 的激活在大多数情况下都会提高基频，但 TA 中度激活时会导致频率下降。我们发现，当振动从涉及整个组织过渡到主要在覆盖层时，频率下降与垂直运动的突然增加有关。振动模式的转变是由 TA 激活后身体与覆盖层刚度比增加引起的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomechanics and Modeling in Mechanobiology 工程技术-工程：生物医学

CiteScore

7.10

自引率

8.60%

发文量

119

审稿时长

6 months

期刊介绍： Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that (1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury, (2) identify and quantify mechanosensitive responses and their mechanisms, (3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and (4) report discoveries that advance therapeutic and diagnostic procedures. Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.