The Inflammatory Response and Long-Term Outcomes Between Open and Laparoscopic Pancreatoduodenectomy:A Propensity-Matched Single-Institution Study.

IF 1.1 4区 医学 Q3 SURGERY
Jiaping Wang, Shuang Yu, Shun Liu, Xue Liang, Shupeng Wang, Lin Li
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引用次数: 0

Abstract

Background: In recent years, although laparoscopic pancreatoduodenectomy (LPD) has experienced rapid development both domestically and internationally, however, there are still varying opinions toward LPD. Methods: From January 2020 to July 2022, the data were collected. We compared the inflammatory response at various postoperative time points and evaluated long-term outcomes between the two groups. Results: In the early stage, the LPD group exhibited lower values of white blood cells, C-reactive protein, neutrophils, and platelets after surgery compared with open pancreatoduodenectomy (OPD) (P all<0.05). However, no statistically significant differences were observed in terms of procalcitonin, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio. Before propensity score matching, no statistical significance was observed between two groups, whether in terms of disease-free survival (DFS) (P = .406) or overall survival (OS) (P = .851). However, to further control for confounding factors, propensity score matching was used. The analysis revealed that DFS still showed no significant difference (P = .928), but, in the term of OS, a statistical significance was observed between the two groups. Conclusion: LPD demonstrates a comparable long-term outcomes to OPD and even slightly superior OS. Moreover, the LPD group exhibits a lower inflammatory response during early postoperative period.

开腹胰十二指肠切除术与腹腔镜胰十二指肠切除术的炎症反应和长期疗效:倾向匹配单机构研究。
背景:近年来,虽然腹腔镜胰十二指肠切除术(LPD)在国内外得到了快速发展,但人们对 LPD 的看法仍不尽相同。研究方法收集2020年1月至2022年7月的数据。我们比较了两组患者在术后不同时间点的炎症反应,并评估了两组患者的长期疗效。结果在早期阶段,与开放性胰十二指肠切除术(OPD)(P allP = .406)或总生存率(OS)(P = .851)相比,LPD 组术后的白细胞、C 反应蛋白、中性粒细胞和血小板值较低。不过,为了进一步控制混杂因素,采用了倾向评分匹配法。分析结果显示,DFS仍无显著差异(P = .928),但在OS方面,两组之间存在统计学意义。结论LPD的长期疗效与OPD相当,OS甚至略胜一筹。此外,LPD 组在术后早期的炎症反应较低。
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来源期刊
CiteScore
2.90
自引率
0.00%
发文量
163
审稿时长
3 months
期刊介绍: Journal of Laparoendoscopic & Advanced Surgical Techniques (JLAST) is the leading international peer-reviewed journal for practicing surgeons who want to keep up with the latest thinking and advanced surgical technologies in laparoscopy, endoscopy, NOTES, and robotics. The Journal is ideally suited to surgeons who are early adopters of new technology and techniques. Recognizing that many new technologies and techniques have significant overlap with several surgical specialties, JLAST is the first journal to focus on these topics both in general and pediatric surgery, and includes other surgical subspecialties such as: urology, gynecologic surgery, thoracic surgery, and more.
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