Patient Perception of Cough in Interstitial Lung Disease; Impact of Cough Hypersensitivity.

IF 4.6 2区医学 Q1 RESPIRATORY SYSTEM

Lung Pub Date : 2024-08-01 Epub Date: 2024-07-08 DOI:10.1007/s00408-024-00723-0

B Hirons, K Rhatigan, L Wright, H Kesavan, E Mackay, P S P Cho, S S Birring, K J Myall

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引用次数: 0

Abstract

Introduction: Cough is common in interstitial lung disease (ILD) and is associated with disease progression, yet its mechanisms are understudied. We investigated cough hypersensitivity features and impact in ILD.

Methods: Participants with ILD and cough (n = 195) completed a multiple choice and free text questionnaire on cough sensations/triggers and impacts.

Results: The majority of participants were male (54%), aged > 65 (64%), with idiopathic pulmonary fibrosis (IPF, 75%). Common cough triggers were body position (74%), physical activity (72%), and talking (62%). Common laryngeal sensations were globus (43%), and itch/tickle (42%). Cough impacted everyday life in 55%, and all activities in 31%, causing exhaustion (59%), social embarrassment (70%), urinary incontinence (46% females), and syncope/pre-syncope (12%). The total number of cough-provoking sensations/triggers correlated with impacts; ρ = 0.73, p < 0.001.

Conclusion: Cough hypersensitivity symptoms are prevalent in ILD and detrimentally affect quality of life. Further studies investigating mechanisms of cough hypersensitivity and targeted pharmacotherapy are warranted.

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间质性肺病患者对咳嗽的感知；咳嗽过敏的影响。

导言：咳嗽在间质性肺病（ILD）中很常见，并与疾病进展有关，但其机制尚未得到充分研究。我们调查了 ILD 中咳嗽超敏反应的特征及其影响：方法：患有 ILD 和咳嗽的参与者（n = 195）填写了一份关于咳嗽感觉/诱因和影响的多项选择和自由文本问卷：大多数参与者为男性（54%），年龄大于 65 岁（64%），患有特发性肺纤维化（IPF，75%）。常见的咳嗽诱因是体位（74%）、体力活动（72%）和说话（62%）。常见的喉部感觉是咽痛（43%）和痒/搔痒（42%）。55%的患者因咳嗽影响日常生活，31%的患者因咳嗽影响所有活动，导致精疲力竭（59%）、社交尴尬（70%）、尿失禁（46%女性）和晕厥/晕厥前症状（12%）。引起咳嗽的感觉/诱因总数与影响相关；ρ = 0.73，p 结论：咳嗽过敏症状是一种常见的慢性疾病：咳嗽过敏症状在 ILD 中很普遍，并对生活质量产生不利影响。有必要对咳嗽过敏的机制和针对性药物疗法进行进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lung 医学-呼吸系统

CiteScore

9.10

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.