Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development.

IF 12.6 1区医学 Q1 IMMUNOLOGY

Journal of Experimental Medicine Pub Date : 2024-10-07 Epub Date: 2024-07-09 DOI:10.1084/jem.20230896

Isabel Baldwin, Ellen A Robey

引用次数: 0

Abstract

During thymic development, thymocytes adjust their TCR response based on the strength of their reactivity to self-peptide MHC complexes. This tuning process allows thymocytes with a range of self-reactivities to survive positive selection and contribute to a diverse T cell pool. In this review, we will discuss recent advances in our understanding of how thymocytes tune their responsiveness during positive selection, and we present a "sequential selection" model to explain how MHC specificity influences lineage choice. We also discuss recent evidence for cell type diversity in the medulla and discuss how this heterogeneity may contribute to medullary niches for negative selection and regulatory T cell development.

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胸腺中的自我调整：CD4与CD8血系的承诺和调节性T细胞的发育

在胸腺发育过程中，胸腺细胞会根据对自身肽 MHC 复合物的反应强度调整其 TCR 反应。这一调整过程使具有各种自我反应性的胸腺细胞能够在正向选择中存活下来，并为多样化的T细胞池做出贡献。在这篇综述中，我们将讨论在了解胸腺细胞如何在正向选择过程中调整其反应性方面的最新进展，并提出一个 "顺序选择 "模型来解释MHC特异性如何影响系谱选择。我们还将讨论髓质中细胞类型多样性的最新证据，并讨论这种异质性可能如何有助于髓质中的负向选择壁龛和调节性T细胞的发育。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Experimental Medicine 医学-免疫学

CiteScore

26.60

自引率

1.30%

发文量

189

审稿时长

3-8 weeks

期刊介绍： Since its establishment in 1896, the Journal of Experimental Medicine (JEM) has steadfastly pursued the publication of enduring and exceptional studies in medical biology. In an era where numerous publishing groups are introducing specialized journals, we recognize the importance of offering a distinguished platform for studies that seamlessly integrate various disciplines within the pathogenesis field. Our unique editorial system, driven by a commitment to exceptional author service, involves two collaborative groups of editors: professional editors with robust scientific backgrounds and full-time practicing scientists. Each paper undergoes evaluation by at least one editor from both groups before external review. Weekly editorial meetings facilitate comprehensive discussions on papers, incorporating external referee comments, and ensure swift decisions without unnecessary demands for extensive revisions. Encompassing human studies and diverse in vivo experimental models of human disease, our focus within medical biology spans genetics, inflammation, immunity, infectious disease, cancer, vascular biology, metabolic disorders, neuroscience, and stem cell biology. We eagerly welcome reports ranging from atomic-level analyses to clinical interventions that unveil new mechanistic insights.