Assessment of phonemic verbal fluency in Portuguese patients with multiple sclerosis.

IF 1.8 4区 心理学 Q3 CLINICAL NEUROLOGY
Márcia França, Cláudia Sousa, Patricia Campos, Mariana Rigueiro-Neves, Aristides Ferreira, Ana Margarida Passos, Maria José Sá
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Abstract

Background: Executive dysfunction occurs in 15% to 20% of multiple sclerosis (MS) patients and verbal fluency tests are frequently used to assess this deficit. The Word List Generation (WLG) is one of the most used measures in MS. This study aims to compare the performance of WLG of MS patients and healthy controls and to analyze the influence of clinical and demographic factors on the performance of MS patients.

Methods: One hundred and nine MS patients and an age- and gender-matched group of 138 healthy controls were evaluated with WLG Portuguese version, as well as other tests from the Brief Repeatable Battery of Neuropsychological Tests (BRBN-T), subtests from WAIS, a phonemic fluency test (M, R, and P), and measures of psychological symptomatology and cognitive fatigue. The MS group (70.6% females) was mainly diagnosed with RRMS (89.2%).

Results: The MS group performed significantly lower than healthy controls on the WLG. In the MS group, this performance was significantly correlated with the level of education. Significant differences were found between the two groups regarding cognitive fatigue, with MS patients reporting higher levels than healthy controls. However, this variable was not related to the performance on the WLG for MS patients.

Conclusions: This study suggests that MS is associated with large levels of cognitive decline on the phonemic verbal fluency tests. These results are consistent with other studies and highlight the importance of verbal fluency and cognitive speed measures in the neuropsychological assessment of MS. Deficits on this task seem to be highly related to the level of education of the patient rather than other demographic and clinical factors.

评估葡萄牙籍多发性硬化症患者的语音口头流利程度。
背景:15%到20%的多发性硬化症(MS)患者会出现执行功能障碍,言语流畅性测试常用于评估这种缺陷。单词表生成(WLG)是多发性硬化症中最常用的测量方法之一。本研究旨在比较多发性硬化症患者和健康对照组的 WLG 表现,并分析临床和人口学因素对多发性硬化症患者表现的影响:对 109 名多发性硬化症患者和 138 名年龄与性别匹配的健康对照组进行了葡萄牙语版 WLG 评估,同时还进行了简易可重复神经心理测试组合(BRBN-T)的其他测试、WAIS 的子测试、语音流畅性测试(M、R 和 P)以及心理症状和认知疲劳测量。多发性硬化症组(70.6%为女性)主要确诊为 RRMS(89.2%):MS组在WLG上的表现明显低于健康对照组。多发性硬化症组的表现与受教育程度明显相关。两组患者在认知疲劳方面存在明显差异,多发性硬化症患者的认知疲劳程度高于健康对照组。然而,这一变量与多发性硬化症患者在WLG上的表现无关:本研究表明,多发性硬化症患者在音位言语流利性测试中的认知能力下降程度较大。这些结果与其他研究一致,并强调了语言流畅性和认知速度测量在多发性硬化症神经心理学评估中的重要性。这项任务的缺陷似乎与患者的教育水平而非其他人口和临床因素高度相关。
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来源期刊
CiteScore
3.20
自引率
4.50%
发文量
52
审稿时长
6-12 weeks
期刊介绍: Journal of Clinical and Experimental Neuropsychology ( JCEN) publishes research on the neuropsychological consequences of brain disease, disorders, and dysfunction, and aims to promote the integration of theories, methods, and research findings in clinical and experimental neuropsychology. The primary emphasis of JCEN is to publish original empirical research pertaining to brain-behavior relationships and neuropsychological manifestations of brain disease. Theoretical and methodological papers, critical reviews of content areas, and theoretically-relevant case studies are also welcome.
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