Computerized metric assessment of glandular tissue volume within the peripheral zone of the prostate using combined magnetic resonance imaging and histopathology: Possible pathophysiological implications on prostate cancer development.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
John M Wolpert, Caroline Presson, Nathaniel Kimball, Benjamin Lin, Luis Brandi, Naseem Helo, Werner T W de Riese
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Abstract

Purpose: Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are prevalent urological ailments in elderly males. Numerous clinical studies have revealed an invert association between BPH/prostate size and PCa growth. This study investigates the association between prostate size and total glandular tissue volume of the peripheral zone (GVPZ) using a unique blend of magnetic resonance imaging (MRI) and histo-anatomical imaging technique.

Materials and methods: Patients were selected who underwent both radical prostatectomy and preoperative MRI scans. MRI scans provided quantitative measurements of prostatic zone dimensions, while histo-anatomical slides yielded quantitative data on glandular density of the peripheral zone (PZ) using imaging software. Integration of MRI and histopathology enabled the assessment of the GVPZ. Statistical analysis identified relationships between total prostate volume (TPV) and GVPZ.

Results: Seventy-two patients were selected and 40 cc was determined to be the optimal cutoff for small-to-moderate versus large prostates. Once the two subgroups in TPV were formed, the relationship between TPV and GVPZ was found to be highly significant (p<0.001).

Conclusions: The combination of MRI and histopathology offers a novel approach for precise quantification of glandular tissue within the prostatic PZ. This study corroborates the hypothesis of PZ compression via an enlarging transition zone in larger BPH prostates, resulting in PZ glandular atrophy. Given that most PCa originates in the PZ, these results shed light on the potential protective role of larger BPH prostates against PCa growth.

利用磁共振成像和组织病理学对前列腺外周区腺体组织体积进行计算机计量评估:对前列腺癌发展的可能病理生理学影响。
目的:良性前列腺增生症(BPH)和前列腺癌(PCa)是老年男性常见的泌尿系统疾病。大量临床研究表明,良性前列腺增生/前列腺大小与 PCa 生长之间存在反向关联。本研究采用独特的磁共振成像(MRI)和组织解剖成像技术,研究前列腺大小与外周区腺体组织总量(GVPZ)之间的关系:选取接受根治性前列腺切除术和术前磁共振成像扫描的患者。核磁共振成像扫描提供了前列腺区域尺寸的定量测量数据,而组织解剖切片则利用成像软件提供了外周区(PZ)腺体密度的定量数据。核磁共振成像与组织病理学的结合使我们能够评估前列腺外周区(GVPZ)。统计分析确定了前列腺总体积(TPV)和GVPZ之间的关系:结果:72 名患者被选中,40 毫升被确定为中小型前列腺与大型前列腺的最佳分界线。一旦 TPV 的两个亚组形成,TPV 和 GVPZ 之间的关系被发现具有高度显著性(pConclusions:核磁共振成像与组织病理学的结合为前列腺PZ内腺体组织的精确量化提供了一种新方法。这项研究证实了在较大的良性前列腺增生症前列腺中,PZ 通过扩大的过渡区受到挤压,从而导致 PZ 腺体萎缩的假说。鉴于大多数 PCa 都起源于 PZ,这些结果揭示了较大的良性前列腺增生症前列腺对 PCa 生长的潜在保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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