João Marcos Carvalho-Silva, Ana Beatriz Vilela Teixeira, Marco Antônio Schiavon, Andréa Cândido Dos Reis
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引用次数: 0
Abstract
Aim: To develop a β-AgVO3 gel and evaluate its physicochemical stability and antifungal activity against Candida albicans. Materials & methods: The gel was prepared from the minimum inhibitory concentration (MIC) of β-AgVO3. The physicochemical stability was evaluated by centrifugation, accelerated stability (AS), storage (St), pH, syringability, viscosity and spreadability tests and antifungal activity by the agar diffusion. Results: The MIC was 62.5 μg/ml. After centrifugation, AS and St gels showed physicochemical stability. Lower viscosity and higher spreadability were observed for the higher β-AgVO3 concentration and the minimum force for extrusion was similar for all groups. Antifungal effect was observed only for the β-AgVO3 gel with 20xMIC. Conclusion: The β-AgVO3 gel showed physicochemical stability and antifungal activity.
期刊介绍：
Future Microbiology delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this increasingly important and vast area of research.
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