Polymer-free stents for percutaneous coronary intervention in diabetic patients: a systematic review and meta-analysis.

IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Future cardiology Pub Date : 2024-01-01 Epub Date: 2024-07-09 DOI:10.1080/14796678.2024.2370688

Filippo Luca Gurgoglione, Davide Donelli, Michele Antonelli, Luigi Vignali, Giorgio Benatti, Emilia Solinas, Iacopo Tadonio, Giulia Magnani, Andrea Denegri, Davide Lazzeroni, Rocco Antonio Montone, Riccardo C Bonadonna, Francesco Nicolini, Diego Ardissino, Giampaolo Niccoli

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引用次数: 0

Abstract

Aim: To compare the efficacy of polymer-free drug-eluting stents (PF-DES) versus other stents in diabetic patients with coronary artery disease undergoing percutaneous coronary interventions.Materials & methods: A systematic review and meta-analysis were performed to identify pertinent randomized controlled trials. The primary end point was the occurrence of target lesion failure.Results: Eight randomized controlled trials were included for a total of 4854 subjects. The PF-DES group experienced a trend in favor of a lower rate of target lesion failure (Incidence rate ratio = 0.91; p = 0.11) and a significantly lower rate of cardiac mortality, as compared with the control group (Incidence rate ratio = 0.82; p = 0.04). However, statistical significance was lost if bare-metal stent patients were excluded and a trend in favor of the PF-DES strategy was reported only for cardiac mortality.Conclusion: PF-DES could be a valuable strategy in diabetic patients with coronary artery disease undergoing percutaneous coronary interventions.

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用于糖尿病患者经皮冠状动脉介入治疗的不含聚合物的支架：系统综述和荟萃分析。

目的：比较无聚合物药物洗脱支架（PF-DES）与其他支架在接受经皮冠状动脉介入治疗的糖尿病冠心病患者中的疗效。材料与方法：进行了系统回顾和荟萃分析，以确定相关的随机对照试验。主要终点是靶病变失败的发生率。结果：共纳入了 8 项随机对照试验，受试者总数为 4854 人。与对照组相比，PF-DES 组的靶病变失败率呈下降趋势（发生率比 = 0.91；P = 0.11），心脏死亡率显著降低（发生率比 = 0.82；P = 0.04）。然而，如果将裸金属支架患者排除在外，统计意义就不复存在了，只有在心脏死亡率方面，PF-DES 策略有获胜的趋势。结论：对于接受经皮冠状动脉介入治疗的糖尿病冠心病患者来说，PF-DES 是一种有价值的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.