Integrin-mediated ILC2 adhesion protects against lupus nephritis

IF 29.4 1区医学 Q1 RHEUMATOLOGY

Nature Reviews Rheumatology Pub Date : 2024-07-08 DOI:10.1038/s41584-024-01140-6

Jessica McHugh

引用次数: 0

Abstract

Type 2 innate lymphoid cells protect against kidney inflammation in lupus nephritis, and enhancing their adhesion via integrin α4β7 upregulation, particularly through IL-33 treatment, could be a promising therapeutic approach.

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整合素介导的 ILC2 粘附可预防狼疮性肾炎

2型先天性淋巴细胞能保护狼疮肾炎患者的肾脏免受炎症侵袭，而通过整合素α4β7上调（尤其是通过IL-33治疗）增强其粘附性可能是一种很有前景的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Rheumatology 医学-风湿病学

CiteScore

29.90

自引率

0.90%

发文量

137

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Rheumatology is part of the Nature Reviews portfolio of journals. The journal scope covers the entire spectrum of rheumatology research. We ensure that our articles are accessible to the widest possible audience.