Microglia are dispensable for experience-dependent refinement of mouse visual circuitry

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2024-07-08 DOI:10.1038/s41593-024-01706-3

Thomas C. Brown, Emily C. Crouse, Cecilia A. Attaway, Dana K. Oakes, Sarah W. Minton, Bart G. Borghuis, Aaron W. McGee

引用次数: 0

Abstract

To test the hypothesized crucial role of microglia in the developmental refinement of neural circuitry, we depleted microglia from mice of both sexes with PLX5622 and examined the experience-dependent maturation of visual circuitry and function. We assessed retinal function, receptive field tuning of visual cortex neurons, acuity and experience-dependent plasticity. None of these measurements detectibly differed in the absence of microglia, challenging the role of microglia in sculpting neural circuits. The authors test the model that microglia are crucial for the developmental refinement of neural circuitry by depleting them with PLX5622. Microglia prove dispensable for the experience-dependent maturation of visual circuitry during development.

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小胶质细胞对小鼠视觉回路的经验依赖性完善是不可或缺的

为了验证小胶质细胞在神经回路发育完善过程中的关键作用，我们用 PLX5622 清除了雌雄小鼠的小胶质细胞，并研究了视觉回路和功能的经验依赖性成熟。我们评估了视网膜功能、视觉皮层神经元的感受野调谐、敏锐度和经验依赖性可塑性。在没有小胶质细胞的情况下，这些测量结果都没有明显的差异，这对小胶质细胞在神经回路形成过程中的作用提出了质疑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.

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