Intracranial Volume Is Driven by Both Genetics and Early Life Exposures: The SOL-INCA-MRI Study.

IF 3.4 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Ethnicity & Disease Pub Date : 2024-07-02 eCollection Date: 2024-02-01 DOI:10.18865/ed.34.2.103

Tamar Sofer, Einat Granot-Hershkovitz, Wassim Tarraf, Paola Filigrana, Carmen R Isasi, Shakira F Suglia, Robert Kaplan, Kent Taylor, Martha L Daviglus, Fernando D Testai, Donglin Zeng, Jianwen Cai, Myriam Fornage, Hector M González, Charles DeCarli

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Abstract

Intracranial volume (ICV) reflects maximal brain development and is associated with later-life cognitive abilities. We quantified ICV among first- and second-generation Hispanic and Latino adults from the Study of Latinos-Investigation of Cognitive Aging - MRI (SOL-INCA-MRI), estimated ICV heritability, and tested its associations with previously reported genetic variants, both individually and as a genetic risk score (GRS). We also estimated the association of ICV with early life environmental measures: nativity or age of immigration and parental education. The estimated heritability of ICV was 19% (95% CI, 0.1%-56%) in n=1781 unrelated SOL-INCA-MRI individuals. Four of 10 tested genetic variants were associated with ICV and an increase of 1 SD of the ICV-GRS was associated with an increase of 10.37 cm³ in the ICV (95% CI, 5.29-15.45). Compared to being born in the continental United States, immigrating to the United States at age 11 years or older was associated with 24 cm³ smaller ICV (95% CI, -39.97 to -8.06). Compared to both parents having less than high-school education, at least 1 parent completing high-school education was associated with 15.4 cm³ greater ICV (95% CI, 4.46-26.39). These data confirm the importance of early life health on brain development.

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颅内容积由遗传和生命早期暴露共同驱动：SOL-INCA-MRI 研究。

颅内容积（ICV）反映了大脑的最大发育程度，并与晚年的认知能力有关。我们对 "拉美裔认知老化调查-核磁共振成像研究"（SOL-INCA-MRI）中第一代和第二代拉美裔成年人的颅内容积进行了量化，估算了颅内容积的遗传率，并测试了颅内容积与之前报道的遗传变异的关联，包括单独遗传变异和遗传风险评分（GRS）。我们还估算了 ICV 与早期生活环境因素的关系：出生地或移民年龄以及父母的教育程度。在 1781 名无血缘关系的 SOL-INCA-MRI 患者中，ICV 的遗传率估计为 19%（95% CI，0.1%-56%）。在 10 个受测基因变异中，有 4 个与 ICV 相关，ICV-GRS 增加 1 SD 与 ICV 增加 10.37 立方厘米相关（95% CI，5.29-15.45）。与出生在美国大陆相比，11 岁或 11 岁以上移民到美国与 ICV 变小 24 立方厘米有关（95% CI，-39.97 至 -8.06）。与父母双方均未接受过高中教育相比，父母至少有一方完成高中教育与 ICV 增加 15.4 立方厘米有关（95% CI，4.46-26.39）。这些数据证实了生命早期健康对大脑发育的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ethnicity & Disease 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.30

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Ethnicity & Disease is an international journal that exclusively publishes information on the causal and associative relationships in the etiology of common illnesses through the study of ethnic patterns of disease. Topics focus on: ethnic differentials in disease rates;impact of migration on health status; social and ethnic factors related to health care access and health; and metabolic epidemiology. A major priority of the journal is to provide a forum for exchange between the United States and the developing countries of Europe, Africa, Asia, and Latin America.