Uric acid and cardiovascular diseases: a reappraisal.

Postgraduate medicine Pub Date : 2024-08-01 Epub Date: 2024-07-09 DOI:10.1080/00325481.2024.2377952
Akruti Patel Prabhakar, Angel Lopez-Candales
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Abstract

Serum uric acid (SUA) has garnered an increased interest in recent years as an important determinant of cardiovascular disease. Uric acid, a degradation product of purine metabolism, is affected by several inheritable and acquired factors, such as genetic mutation, metabolic syndrome, chronic kidney disease, and medication interactions. Even though elevated SUA have been commonly associated with the development of gout, it has significant impact in the development of hypertension, metabolic syndrome, and cardiovascular disease. Uric acid, in both crystalline and soluble forms, plays a key role in the induction of inflammatory cascade and development of atherosclerotic diseases. This concise reappraisal emphasizes key features about the complex and challenging role of uric acid in the development and progression of atherosclerosis and cardiovascular disease. It explores the pathogenesis and historical significance of uric acid, highlights the complex interplay between uric acid and components of metabolic syndrome, focuses on the pro-inflammatory and pro-atherogenic effects of uric acid, as well as discusses the role of urate lowering therapies in mitigating the risk of cardiovascular disease while providing the latest evidence to the healthcare professionals focusing on the clinical importance of SUA levels with regards to cardiovascular disease.

尿酸与心血管疾病:重新评估。
近年来,血清尿酸(SUA)作为心血管疾病的重要决定因素越来越受到关注。尿酸是嘌呤代谢的降解产物,受多种遗传和后天因素的影响,如基因突变、代谢综合征、慢性肾病和药物相互作用。尽管尿酸升高通常与痛风的发生有关,但它对高血压、代谢综合征和心血管疾病的发生也有重大影响。结晶和可溶形式的尿酸在诱导炎症级联反应和动脉粥样硬化疾病的发展中起着关键作用。这篇简明扼要的综述强调了尿酸在动脉粥样硬化和心血管疾病的发生和发展过程中复杂而具有挑战性作用的关键特征。它探讨了尿酸的致病机理和历史意义,强调了尿酸与代谢综合征成分之间复杂的相互作用,重点关注尿酸的促炎和促动脉粥样硬化作用,并讨论了降尿酸疗法在降低心血管疾病风险方面的作用,同时为医疗保健专业人员提供了最新的证据,关注 SUA 水平对心血管疾病的临床重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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