Role of S100β in Patients with Unstable Angina Pectoris: Insights from Quantitative Flow Ratio

IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Zhihao Liu , Jun Wang , Fuding Guo , Tianyou Xu , Fu Yu , Qiang Deng , Wuping Tan , Shoupeng Duan , Lingpeng Song , Yijun Wang , Ji Sun , Liping Zhou , Yueyi Wang , Xiaoya Zhou , Hao Xia , Hong Jiang
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引用次数: 0

Abstract

Background and objective

Disturbed autonomic nervous system (ANS) may promote inflammatory, immune, and oxidative stress responses, which may increase the risk of acute coronary events. S100β has been proposed as a biomarker of neuronal injury that would provide an insightful understanding of the crosstalk between the ANS, immune-inflammatory cells, and plaques that drive atherosclerosis. This study investigates the correlation between S100β, and functional coronary stenosis as determined by quantitative flow ratio (QFR).

Methods

Patients with unstable angina pectoris (UAP) scheduled for coronary angiography and QFR were retrospectively enrolled. Serum S100β levels were determined by enzyme-linked immunosorbent assay. The Gensini score was used to estimate the extent of atherosclerotic lesions and the cumulative sum of three-vessel QFR (3V-QFR) was calculated to estimate the total atherosclerotic burden.

Results

Two hundred thirty-three patients were included in this study. Receiver operator characteristic (ROC) curve indicated that S100β>33.28 pg/mL predicted functional ischemia in patients with UAP. Multivariate logistic analyses showed that a higher level of S100β was independently correlated with a functional ischemia-driven target vessel (QFR ≤0.8). This was also closely correlated with the severity of coronary lesions, as measured by the Gensini score (OR = 5.058, 95% CI: 2.912–8.793, p <0.001). According to 3V-QFR, S100β is inversely associated with total atherosclerosis burden (B = –0.002, p <0.001).

Conclusions

S100β was elevated in the functional ischemia stages of UAP. It was independently associated with coronary lesion severity as assessed by Gensini score and total atherosclerosis burden as estimated by 3V-QFR in patients with UAP.

S100β 在不稳定型心绞痛患者中的作用:定量血流比率的启示。
背景和目的:自律神经系统(ANS)紊乱可能会促进炎症、免疫和氧化应激反应,从而增加急性冠状动脉事件的风险。S100β 被认为是神经元损伤的生物标志物,它将有助于深入了解自律神经系统、免疫炎症细胞和动脉粥样硬化斑块之间的相互影响。本研究探讨了 S100β 与定量血流比(QFR)测定的功能性冠状动脉狭窄之间的相关性:方法:研究人员回顾性纳入了计划接受冠状动脉造影术和定量血流比测定的不稳定型心绞痛(UAP)患者。血清 S100β 水平通过酶联免疫吸附试验测定。Gensini 评分用于估算动脉粥样硬化病变的范围,三血管 QFR 的累积总和(3V-QFR)用于估算动脉粥样硬化的总负担:本研究共纳入 233 名患者。接收器操作特征(ROC)曲线显示,S100β>33.28 pg/mL可预测UAP患者的功能性缺血。多变量逻辑分析表明,较高水平的 S100β 与功能性缺血驱动的靶血管(QFR ≤0.8)独立相关。这也与以 Gensini 评分衡量的冠状动脉病变严重程度密切相关(OR = 5.058,95% CI:2.912-8.793,p 结论:S100β 的升高与冠状动脉病变的严重程度密切相关:S100β在UAP功能性缺血阶段升高。在 UAP 患者中,S100β 与用 Gensini 评分评估的冠状动脉病变严重程度和用 3V-QFR 估算的总动脉粥样硬化负荷有独立关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Archives of Medical Research
Archives of Medical Research 医学-医学:研究与实验
CiteScore
12.50
自引率
0.00%
发文量
84
审稿时长
28 days
期刊介绍: Archives of Medical Research serves as a platform for publishing original peer-reviewed medical research, aiming to bridge gaps created by medical specialization. The journal covers three main categories - biomedical, clinical, and epidemiological contributions, along with review articles and preliminary communications. With an international scope, it presents the study of diseases from diverse perspectives, offering the medical community original investigations ranging from molecular biology to clinical epidemiology in a single publication.
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