Flexible circuit-based spatially aware modular optical brain imaging system for high-density measurements in natural settings.

Abstract

Significance: Functional near-infrared spectroscopy (fNIRS) presents an opportunity to study human brains in everyday activities and environments. However, achieving robust measurements under such dynamic conditions remains a significant challenge.

Aim: The modular optical brain imaging (MOBI) system is designed to enhance optode-to-scalp coupling and provide a real-time probe three-dimensional (3D) shape estimation to improve the use of fNIRS in everyday conditions.

Approach: The MOBI system utilizes a bendable and lightweight modular circuit-board design to enhance probe conformity to head surfaces and comfort for long-term wearability. Combined with automatic module connection recognition, the built-in orientation sensors on each module can be used to estimate optode 3D positions in real time to enable advanced tomographic data analysis and motion tracking.

Results: Optical characterization of the MOBI detector reports a noise equivalence power of 8.9 and $7.3\mathrm{pW}/\sqrt{\mathrm{Hz}}$ at 735 and 850 nm, respectively, with a dynamic range of 88 dB. The 3D optode shape acquisition yields an average error of 4.2 mm across 25 optodes in a phantom test compared with positions acquired from a digitizer. Results for initial in vivo validations, including a cuff occlusion and a finger-tapping test, are also provided.

Conclusions: To the best of our knowledge, the MOBI system is the first modular fNIRS system featuring fully flexible circuit boards. The self-organizing module sensor network and automatic 3D optode position acquisition, combined with lightweight modules ( $18g/\text{module}$ ) and ergonomic designs, would greatly aid emerging explorations of brain function in naturalistic settings.