Pericentromeric satellite RNAs as flexible protein partners in the regulation of nuclear structure.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Mariana Lopes, Sandra Louzada, Margarida Gama-Carvalho, Raquel Chaves
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引用次数: 0

Abstract

Pericentromeric heterochromatin is mainly composed of satellite DNA sequences. Although being historically associated with transcriptional repression, some pericentromeric satellite DNA sequences are transcribed. The transcription events of pericentromeric satellite sequences occur in highly flexible biological contexts. Hence, the apparent randomness of pericentromeric satellite transcription incites the discussion about the attribution of biological functions. However, pericentromeric satellite RNAs have clear roles in the organization of nuclear structure. Silencing pericentromeric heterochromatin depends on pericentromeric satellite RNAs, that, in a feedback mechanism, contribute to the repression of pericentromeric heterochromatin. Moreover, pericentromeric satellite RNAs can also act as scaffolding molecules in condensate subnuclear structures (e.g., nuclear stress bodies). Since the formation/dissociation of nuclear condensates provides cell adaptability, pericentromeric satellite RNAs can be an epigenetic platform for regulating (sub)nuclear structure. We review current knowledge about pericentromeric satellite RNAs that, irrespective of the meaning of biological function, should be functionally addressed in regular and disease settings. This article is categorized under: RNA Methods > RNA Analyses in Cells RNA in Disease and Development > RNA in Disease.

核周边卫星 RNA 是调节核结构的灵活蛋白质伙伴。
近染色质异染色质主要由卫星 DNA 序列组成。尽管卫星 DNA 序列在历史上与转录抑制有关,但有些中心染色质周围的卫星 DNA 序列也会被转录。中心周卫星序列的转录事件发生在高度灵活的生物环境中。因此,中心染色体周围卫星转录的明显随机性引发了有关生物功能归属的讨论。然而,近中心染色质卫星 RNA 在核结构的组织中具有明确的作用。沉默周染色质异染色质依赖于周染色质卫星 RNA,后者在反馈机制中有助于抑制周染色质异染色质。此外,围中心染色质卫星 RNA 还可以在凝聚的亚核结构(如核应激体)中充当支架分子。由于核凝聚体的形成/解离提供了细胞的适应性,因此包心染色质卫星 RNA 可以成为调节(亚)核结构的表观遗传平台。我们回顾了目前有关核周卫星 RNA 的知识,无论其生物学功能的意义如何,都应在常规和疾病环境中加以功能性处理。本文归类于RNA 方法 > 细胞中的 RNA 分析 疾病和发育中的 RNA > 疾病中的 RNA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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