Adolescent sleep patterns, genetic predisposition, and risk of multiple sclerosis.

IF 5.6 2区医学 Q1 Medicine

Sleep Pub Date : 2024-10-11 DOI:10.1093/sleep/zsae156

Eva Johansson, Tomas Olsson, Pernilla Strid, Ingrid Kockum, Lars Alfredsson, Anna Karin Hedström

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引用次数: 0

Abstract

Study objectives: Shift work, insufficient sleep, and poor sleep quality at young age have been associated with increased risk of multiple sclerosis (MS). This study aimed to investigate the potential interaction between aspects of inadequate sleep (short sleep, phase shift, and poor sleep quality) during adolescence and HLA-DRB1*15:01 in relation to MS risk.

Methods: We used a Swedish population-based case-control study (1253 cases and 1766 controls). Participants with different sleep patterns during adolescence and HLA-DRB1*15:01 status were compared regarding MS risk by calculating odds ratios with 95% confidence intervals (CI) using logistic regression models. Additive interaction between aspects of inadequate sleep and HLA-DRB1*15:01 status was assessed by calculating the attributable proportion due to interaction (AP) with 95% CI.

Results: Short sleep duration (<7 hours/night) during adolescence acted synergistically with HLA-DRB1*15:01, increasing the risk of MS (AP 0.38, 95% CI: 0.01 to 0.75, p = .04). Similarly, subjective low sleep quality during adolescence interacted with HLA-DRB1*15:01 regarding risk of MS (AP 0.30, 95% CI: 0.06 to 0.56, p = .03), whereas phase shift did not significantly influence the risk of the disease, irrespective of HLA-DRB1*15:01 status.

Conclusions: Our findings underscore the importance of addressing inadequate sleep during adolescence, particularly in the context of the HLA-DRB1*15:01 allele, as it appears to amplify the risk of subsequently developing MS.

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青少年睡眠模式、遗传倾向和多发性硬化症风险。

研究目的：年轻时轮班工作、睡眠不足和睡眠质量差与多发性硬化症（MS）风险增加有关。本研究旨在调查青春期睡眠不足（睡眠时间短、相位变换和睡眠质量差）与 HLA-DRB1*15:01 之间的潜在相互作用与多发性硬化症风险的关系：我们采用了一项基于瑞典人口的病例对照研究（1253 例病例和 1766 例对照）。通过使用逻辑回归模型计算几率比（OR）和95%置信区间（CI），比较了青春期不同睡眠模式和HLA-DRB1*15:01状态的受试者患多发性硬化症的风险。通过计算交互作用导致的可归因比例（AP）和 95% 置信区间（CI），评估了睡眠不足与 HLA-DRB1*15:01 状态之间的相加交互作用：结果：睡眠时间短（结论：我们的研究结果强调了解决青春期睡眠不足问题的重要性，尤其是在HLA-DRB1*15:01等位基因的情况下，因为睡眠不足似乎会放大随后罹患多发性硬化症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

期刊介绍： SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.