Prognostic impact of cytokines and chemokines in bronchoalveolar lavage fluid on acute exacerbation of fibrosing interstitial lung disease

IF 3.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Respiratory medicine Pub Date : 2024-07-05 DOI:10.1016/j.rmed.2024.107721

Katsuyuki Furuta , Daichi Fujimoto , Atsushi Matsunashi , Ryota Shibaki , Shinnosuke Taniya , Masanori Tanaka , Yuri Shimada , Kazuma Nagata , Keisuke Tomii , Nobuyuki Yamamoto

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引用次数: 0

Abstract

Background and objective

Acute exacerbation of fibrosing interstitial lung disease (AE-FILD) is a serious condition with a high mortality rate. We aimed to comprehensively analyze cytokines in bronchoalveolar lavage fluid and their association with the clinical course of AE-FILD.

Methods

We retrospectively enrolled 60 patients with AE-FILD who underwent bronchoalveolar lavage. We comprehensively measured 44 cytokines and chemokines in the obtained bronchoalveolar lavage fluid using a Luminex analyzer. Patients were grouped into those who died within 90 days (non-survival group) and survived beyond 90 days (survival group) to investigate the association of the levels of cytokines and chemokines with mortality.

Results

The levels of matrix metalloproteinase 1 (p = 0.003), granulocyte-macrophage colony-stimulating factor (p = 0.040), interleukin 6 (p = 0.047), interleukin 8 (p = 0.050), monocyte chemoattractant protein-1 (p = 0.043), and eotaxin (p = 0.044) were significantly higher in the non-survival group than in the survival group. In the receiver operating characteristic analysis, their areas under the curve were 0.80, 0.68, 0.71, 0.70, 0.70, and 0.72, respectively. Using machine learning with these six cytokines and chemokines, the predictive accuracy for the survival group was 0.94.

Conclusions

Our study demonstrated that several cytokines and chemokines in bronchoalveolar lavage fluid could be prognostic predictors in patients with AE-FILD.

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支气管肺泡灌洗液中的细胞因子和趋化因子对纤维化间质性肺病急性加重的预后影响

背景和目的：纤维化间质性肺疾病急性加重期（AE-FILD）是一种严重的疾病，死亡率很高。我们旨在全面分析支气管肺泡灌洗液中的细胞因子及其与 AE-FILD 临床病程的关系：我们回顾性地纳入了 60 例接受支气管肺泡灌洗的 AE-FILD 患者。我们使用 Luminex 分析仪全面测定了支气管肺泡灌洗液中的 44 种细胞因子和趋化因子。我们将患者分为 90 天内死亡组（非存活组）和 90 天后存活组（存活组），以研究细胞因子和趋化因子水平与死亡率的关系：结果：非存活组的基质金属蛋白酶1（p = 0.003）、粒细胞-巨噬细胞集落刺激因子（p = 0.040）、白细胞介素6（p = 0.047）、白细胞介素8（p = 0.050）、单核细胞趋化蛋白-1（p = 0.043）和依他命素（p = 0.044）水平明显高于存活组。在接收者操作特征分析中，它们的曲线下面积分别为 0.80、0.68、0.71、0.70、0.70 和 0.72。通过对这六种细胞因子和趋化因子进行机器学习，生存组的预测准确率为 0.94：我们的研究表明，支气管肺泡灌洗液中的几种细胞因子和趋化因子可以预测AE-FILD患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.

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