Therapeutic Potential of Brassica oleracea and Raphanus sativus Aqueous Extracts on a Prediabetic Rat Model.

IF 1.7 3区农林科学 Q4 CHEMISTRY, MEDICINAL

Journal of medicinal food Pub Date : 2024-07-01 Epub Date: 2024-07-08 DOI:10.1089/jmf.2023.0022

Jonatan Jafet Uuh Narvaez, Juan José Acevedo Fernández, Elizabeth Negrete León, José Iván Martínez Rivera, José Leonardo Guillermo Cordero, Maira Rubi Segura Campos

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Abstract

Type 2 diabetes (T2D) is a serious health problem, and its prevalence is expected to increase worldwide in the years ahead. Cruciferous vegetables such as Brassica oleracea var. capitata L. (green cabbage) and Raphanus sativus L. (radish) have therapeutic properties that can be used to support the treatment of T2D. This study evaluated the effect of B. oleracea (BAE) and R. sativus (RAE) aqueous extracts on zoometric parameters, glycemic profiles, and pancreas and liver in prediabetic rats induced by a high-sucrose diet (HSD). BAE and RAE were administered to male HSD-induced Wistar rats (n = 35) at 5 and 10 mg/kg doses for 5 weeks. Zoometric and biochemical changes were measured, and then the pancreas and liver histological preparations were analyzed to observe the protective effect. BAE decreased feed intake and weight gain. Both extracts decreased fasting glucose and insulin levels compared with control (not treated), although not significantly (P > .05). The extracts significantly (P < .05) reduced homeostatic model assessment for insulin resistance, homeostasis model assessment of β-cell function, and glucose intolerance, similar to metformin control. In addition, minor damage occurred in the pancreas and liver. The results indicated that BAE and RAE decreased weight gain, improved glucose regulation, and protected the pancreas and liver in HSD rats. Therefore, they have multiple therapeutical properties and may be helpful in the prevention of T2D.

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甘蓝和油菜水提取物对糖尿病前期大鼠模型的治疗潜力

2型糖尿病（T2D）是一个严重的健康问题，预计未来几年其发病率将在全球范围内上升。十字花科蔬菜，如 Brassica oleracea var.本研究评估了 B. oleracea（BAE）和 R. sativus（RAE）水提取物对高蔗糖饮食（HSD）诱导的糖尿病前期大鼠的动物计量参数、血糖谱、胰腺和肝脏的影响。给雄性 HSD 诱导的 Wistar 大鼠（n = 35）服用 BAE 和 RAE，剂量分别为 5 毫克/千克和 10 毫克/千克，连续服用 5 周。测量动物计量和生化变化，然后分析胰腺和肝脏组织学制备物，观察其保护作用。BAE 降低了采食量和增重。与对照组（未处理）相比，两种提取物都能降低空腹血糖和胰岛素水平，但不显著（P > .05）。与二甲双胍对照组相比，这两种提取物能明显（P < .05）降低胰岛素抵抗的稳态模型评估、β细胞功能的稳态模型评估和葡萄糖不耐受。此外，胰腺和肝脏也出现了轻微损伤。结果表明，BAE 和 RAE 可减少 HSD 大鼠的体重增加，改善血糖调节，保护胰腺和肝脏。因此，它们具有多种治疗特性，可能有助于预防 T2D。

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来源期刊

Journal of medicinal food 医学-食品科技

CiteScore

4.50

自引率

0.00%

发文量

154

审稿时长

4.5 months

期刊介绍： Journal of Medicinal Food is the only peer-reviewed journal focusing exclusively on the medicinal value and biomedical effects of food materials. International in scope, the Journal advances the knowledge of the development of new food products and dietary supplements targeted at promoting health and the prevention and treatment of disease.