Association of dietary intake and serum concentration of omega-3 fatty acids on celiac disease: evidence from observational study and Mendelian randomization.

IF 2.3 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Tongtong Bai, Juanjuan Peng, Chengyu Wu
{"title":"Association of dietary intake and serum concentration of omega-3 fatty acids on celiac disease: evidence from observational study and Mendelian randomization.","authors":"Tongtong Bai, Juanjuan Peng, Chengyu Wu","doi":"10.1097/MEG.0000000000002814","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The association between omega-3 fatty acids (O3FA) and celiac disease lacks sufficient investigation.</p><p><strong>Methods: </strong>Utilizing data gleaned from the 2009 to 2014 National Health and Nutrition Examination Survey (NHANES), this research comprises a sample of 13 403 adults, each aged 20 years and above. We conducted a multivariable logistic regression analysis to assess the association between dietary intake of O3FA and celiac disease. Subsequently, a two-sample Mendelian randomization was performed to estimate the unconfounded causal relationship between serum O3FA and celiac disease. The principal analytical strategy utilized the inverse-variance weighted methodology.</p><p><strong>Results: </strong>In this cross-sectional study, 48 occurrences (0.36%) of celiac disease were encompassed. In the multivariable model, there was no association between dietary intake of O3FA and cases of celiac disease (odds ratio: 1.12, 95% confidence interval: 0.47-2.66, P  = 0.792). However, serum levels of O3FA determined by genetic assay were correlated with celiac disease (inverse-variance weighted, β = 0.2439, P  = 0.0287), with no evidence of horizontal pleiotropy ( P  = 0.3689).</p><p><strong>Conclusion: </strong>The dietary consumption of O3FA did not exhibit an association with the risk of celiac disease in this cross-sectional investigation. However, a correlation between celiac disease and serum levels of O3FA was observed in the Mendelian randomization. Further investigations, including human clinical trials, are warranted.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"1101-1108"},"PeriodicalIF":2.3000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Gastroenterology & Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MEG.0000000000002814","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: The association between omega-3 fatty acids (O3FA) and celiac disease lacks sufficient investigation.

Methods: Utilizing data gleaned from the 2009 to 2014 National Health and Nutrition Examination Survey (NHANES), this research comprises a sample of 13 403 adults, each aged 20 years and above. We conducted a multivariable logistic regression analysis to assess the association between dietary intake of O3FA and celiac disease. Subsequently, a two-sample Mendelian randomization was performed to estimate the unconfounded causal relationship between serum O3FA and celiac disease. The principal analytical strategy utilized the inverse-variance weighted methodology.

Results: In this cross-sectional study, 48 occurrences (0.36%) of celiac disease were encompassed. In the multivariable model, there was no association between dietary intake of O3FA and cases of celiac disease (odds ratio: 1.12, 95% confidence interval: 0.47-2.66, P  = 0.792). However, serum levels of O3FA determined by genetic assay were correlated with celiac disease (inverse-variance weighted, β = 0.2439, P  = 0.0287), with no evidence of horizontal pleiotropy ( P  = 0.3689).

Conclusion: The dietary consumption of O3FA did not exhibit an association with the risk of celiac disease in this cross-sectional investigation. However, a correlation between celiac disease and serum levels of O3FA was observed in the Mendelian randomization. Further investigations, including human clinical trials, are warranted.

膳食摄入量和血清中欧米茄-3 脂肪酸浓度与乳糜泻的关系:观察研究和孟德尔随机试验的证据。
目的:ω-3 脂肪酸(O3FA)与乳糜泻之间的关系缺乏足够的研究:ω-3脂肪酸(O3FA)与乳糜泻之间的关系缺乏充分调查:本研究利用 2009 年至 2014 年全国健康与营养调查(NHANES)中收集的数据,对 13 403 名年龄在 20 岁及以上的成年人进行了抽样调查。我们进行了多变量逻辑回归分析,以评估膳食中摄入的 O3FA 与乳糜泻之间的关联。随后,我们进行了双样本孟德尔随机分析,以估计血清 O3FA 与乳糜泻之间的无因果关系。主要分析策略采用了逆方差加权法:在这项横断面研究中,共有 48 例(0.36%)乳糜泻患者。在多变量模型中,膳食中摄入的 O3FA 与乳糜泻病例之间没有关联(几率比:1.12,95% 置信区间:0.47-2.66,P = 0.792)。然而,通过基因检测确定的血清中的 O3FA 水平与乳糜泻相关(逆方差加权,β = 0.2439,P = 0.0287),但没有证据表明存在水平多重效应(P = 0.3689):结论:在这项横断面调查中,膳食中摄入的 O3FA 与乳糜泻的风险并无关联。然而,在孟德尔随机试验中观察到乳糜泻与血清中的 O3FA 水平存在相关性。有必要进行进一步的调查,包括人体临床试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.40
自引率
4.80%
发文量
269
审稿时长
1 months
期刊介绍: European Journal of Gastroenterology & Hepatology publishes papers reporting original clinical and scientific research which are of a high standard and which contribute to the advancement of knowledge in the field of gastroenterology and hepatology. The journal publishes three types of manuscript: in-depth reviews (by invitation only), full papers and case reports. Manuscripts submitted to the journal will be accepted on the understanding that the author has not previously submitted the paper to another journal or had the material published elsewhere. Authors are asked to disclose any affiliations, including financial, consultant, or institutional associations, that might lead to bias or a conflict of interest.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信