The long-term effect of COVID-19 infection on olfaction and taste; a prospective analysis.

IF 1.9 3区医学 Q2 OTORHINOLARYNGOLOGY

European Archives of Oto-Rhino-Laryngology Pub Date : 2024-11-01 Epub Date: 2024-07-08 DOI:10.1007/s00405-024-08827-2

Tomer Boldes, Amit Ritter, Ethan Soudry, Dror Diker, Ella Reifen, Eyal Yosefof

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引用次数: 0

Abstract

Purpose: To estimate long-term prognosis of chemosensory dysfunctions among patients recovering from COVID-19 disease.

Methods: Between April 2020 and July 2022, we conducted a prospective, observational study enrolling 48 patients who experienced smell and/or taste dysfunction during the acute-phase of COVID-19. Patients were evaluated for chemosensory function up to 24 months after disease onset.

Results: During the acute-phase of COVID-19, 80% of patients reported anosmia, 15% hyposmia, 63% ageusia, and 33% hypogeusia. At two years' follow-up, 53% still experienced smell impairment, and 42% suffered from taste impairment. Moreover, 63% of patients who reported parosmia remained with olfactory disturbance. Interestingly, we found a negative correlation between visual analogue scale scores for smell and taste impairments during the acute-phase of COVID-19 and the likelihood of long-term recovery.

Conclusion: Our study sheds light on the natural history and long-term follow-up of chemosensory dysfunction in patients recovering from COVID-19 disease. Most patients who initially suffered from smell and/or taste disturbance did not reach full recovery after 2 years follow-up. The severity of impairment may serve as a prognostic indicator for full recovery.

Abstract Image

查看原文本刊更多论文

COVID-19 感染对嗅觉和味觉的长期影响；前瞻性分析。

目的：估计COVID-19疾病康复患者化感功能障碍的长期预后：2020年4月至2022年7月期间，我们开展了一项前瞻性观察研究，招募了48名在COVID-19急性期出现嗅觉和/或味觉功能障碍的患者。患者在发病后24个月内接受了化感功能评估：结果：在COVID-19急性期，80%的患者出现嗅觉障碍，15%的患者出现嗅觉减退，63%的患者出现味觉减退，33%的患者出现味觉减退。在两年的随访中，53%的患者仍有嗅觉障碍，42%的患者有味觉障碍。此外，63%报告有嗅觉障碍的患者仍然存在嗅觉障碍。有趣的是，我们发现 COVID-19 急性期嗅觉和味觉障碍的视觉模拟量表评分与长期康复的可能性呈负相关：我们的研究揭示了COVID-19疾病康复患者化感功能障碍的自然史和长期随访情况。大多数最初出现嗅觉和/或味觉障碍的患者在随访两年后并未完全康复。功能障碍的严重程度可作为完全康复的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Archives of Oto-Rhino-Laryngology 医学-耳鼻喉科学

CiteScore

5.30

自引率

7.70%

发文量

537

审稿时长

2-4 weeks

期刊介绍： Official Journal of European Union of Medical Specialists – ORL Section and Board Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery "European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level. European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.