Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds.

IF 4.6 3区 医学 Q1 NUTRITION & DIETETICS
Current Nutrition Reports Pub Date : 2024-09-01 Epub Date: 2024-07-08 DOI:10.1007/s13668-024-00555-7
Lauren Jun, Ya-Xiong Tao, Thangiah Geetha, Jeganathan Ramesh Babu
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引用次数: 0

Abstract

PURPOSE OF REVIEW: The global obesity epidemic has become a major public health concern, necessitating comprehensive research into its adverse effects on various tissues within the human body. Among these tissues, skeletal muscle has gained attention due to its susceptibility to obesity-related alterations. Mitochondria are primary source of energy production in the skeletal muscle. Healthy skeletal muscle maintains constant mitochondrial content through continuous cycle of synthesis and degradation. However, obesity has been shown to disrupt this intricate balance. This review summarizes recent findings on the impact of obesity on skeletal muscle mitochondria structure and function. In addition, we summarize the molecular mechanism of mitochondrial quality control systems and how obesity impacts these systems. RECENT FINDINGS: Recent findings show various interventions aimed at mitigating mitochondrial dysfunction in obese model, encompassing strategies including caloric restriction and various dietary compounds. Obesity has deleterious effect on skeletal muscle mitochondria by disrupting mitochondrial biogenesis and dynamics. Caloric restriction, omega-3 fatty acids, resveratrol, and other dietary compounds enhance mitochondrial function and present promising therapeutic opportunities.

骨骼肌线粒体的适应性:肥胖、热量限制和膳食化合物的影响。
综述目的:全球肥胖症流行已成为一个重大的公共卫生问题,因此有必要对肥胖症对人体各种组织的不良影响进行全面研究。在这些组织中,骨骼肌因其易受肥胖相关变化的影响而备受关注。线粒体是骨骼肌产生能量的主要来源。健康的骨骼肌通过不断的合成和降解循环维持线粒体含量的恒定。然而,肥胖已被证明会破坏这种错综复杂的平衡。本综述总结了有关肥胖对骨骼肌线粒体结构和功能影响的最新研究成果。此外,我们还总结了线粒体质量控制系统的分子机制以及肥胖如何影响这些系统。最新发现:最近的研究结果表明,各种干预措施旨在减轻肥胖模型中的线粒体功能障碍,包括限制热量摄入和各种膳食化合物。肥胖会破坏线粒体的生物生成和动力学,从而对骨骼肌线粒体产生有害影响。热量限制、欧米茄-3 脂肪酸、白藜芦醇和其他膳食化合物可增强线粒体功能,为治疗带来希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Nutrition Reports
Current Nutrition Reports Agricultural and Biological Sciences-Food Science
CiteScore
7.70
自引率
2.00%
发文量
59
期刊介绍: This journal aims to provide comprehensive review articles that emphasize significant developments in nutrition research emerging in recent publications. By presenting clear, insightful, balanced contributions by international experts, the journal intends to discuss the influence of nutrition on major health conditions such as diabetes, cardiovascular disease, cancer, and obesity, as well as the impact of nutrition on genetics, metabolic function, and public health. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known figures in the field, and an Editorial Board of more than 25 internationally diverse members reviews the annual table of contents, suggests topics of special importance to their country/region, and ensures that topics and current and include emerging research.
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