Sex and Age Differences in Ontogeny of Alloparenting: A Relation to Forebrain DRD1, DRD2, and HTR2A mRNA Expression?

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-07 DOI:10.1002/dev.22524

Yujie Huang, Ruoting Qing, Yu Yang, Ming Li, Jun Gao

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引用次数: 0

Abstract

Alloparenting refers to the practice of caring for the young by individuals other than their biological parents. The relationship between the dynamic changes in psychological functions underlying alloparenting and the development of specific neuroreceptors remains unclear. Using a classic 10-day pup sensitization procedure, together with a pup preference and pup retrieval test on the EPM (elevated plus maze), we showed that both male and female adolescent rats (24 days old) had significantly shorter latency than adult rats (65 days old) to be alloparental, and their motivation levels for pups and objects were also significantly higher. In contrast, adult rats retrieved more pups than adolescent rats even though they appeared to be more anxious on the EPM. Analysis of mRNA expression using real-time-PCR revealed a higher dopamine D₂ receptor (DRD2) receptor expression in adult hippocampus, amygdala, and ventral striatum, along with higher dopamine D₁ receptor (DRD1) receptor expression in ventral striatum compared to adolescent rats. Adult rats also showed significantly higher levels of 5-hydroxytryptamine receptor 2A (HTR2A) receptor expression in the medial prefrontal cortex, amygdala, ventral striatum, and hypothalamus. These results suggest that the faster onset of alloparenting in adolescent rats compared to adult rats, along with the psychological functions involved, may be mediated by varying levels of dopamine DRD1, DRD2, and HTR2A in different forebrain regions.

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异体亲子关系本体发育的性别和年龄差异：与前脑 DRD1、DRD2 和 HTR2A mRNA 表达的关系？

异父异母抚养指的是由亲生父母以外的人照顾年幼子女的做法。异父异母抚养的心理功能动态变化与特定神经受体的发育之间的关系尚不清楚。我们使用经典的 10 天幼仔敏感化程序，并在 EPM（高架加迷宫）上进行幼仔偏好和幼仔检索测试，结果表明，雄性和雌性青少年大鼠（24 天大）的异亲潜伏期明显短于成年大鼠（65 天大），它们对幼仔和物的动机水平也明显更高。相比之下，成年大鼠虽然在EPM中显得更加焦虑，但却比青少年大鼠叼回更多的幼崽。使用实时荧光定量PCR分析mRNA表达发现，与青春期大鼠相比，成年大鼠海马、杏仁核和腹侧纹状体中多巴胺D2受体（DRD2）受体表达较高，腹侧纹状体中多巴胺D1受体（DRD1）受体表达也较高。成年大鼠内侧前额叶皮层、杏仁核、腹侧纹状体和下丘脑中的5-羟色胺受体2A（HTR2A）受体表达水平也明显更高。这些结果表明，与成年大鼠相比，青春期大鼠更快地开始异父异母关系以及相关的心理功能，可能是由不同前脑区域的多巴胺 DRD1、DRD2 和 HTR2A 的不同水平介导的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.