Oral Hygiene With Neutral Electrolyzed Water and Systemic Therapy Increases Gastric Helicobacter pylori Eradication and Reduces Recurrence

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical and Experimental Dental Research Pub Date : 2024-07-07 DOI:10.1002/cre2.927

Victor Hugo Urrutia-Baca, Brenda Astrid Paz-Michel, Alma Nidia Calderon-Porras, Jany Ariadne Jiménez-Del Valle, Wendy Jazmin Alvarez-Fernández, Nicolas Mervitch-Sigal, Mario Alfredo Rodríguez-León, Myriam Angelica De La Garza-Ramos

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引用次数: 0

Abstract

Objectives

Helicobacter pylori gastric infection strongly correlates with gastric diseases such as chronic gastritis, functional dyspepsia, and complications such as peptic ulcers and gastric cancer. In developing countries, systemic therapies are not usually successful due to elevated antibiotic resistance. Additionally, oral H. pylori infection and periodontal disease correlate with gastric treatment failures. This study aimed to explore the effect of an integral therapy, comprising oral hygiene and concomitant systemic treatment, to increase the eradication of gastric infection and recurrences.

Materials and Methods

A prospective, randomized, four-arm, parallel-group, open-label clinical trial was conducted to investigate the efficacy of integral therapy to eradicate gastric H. pylori infection and avoid recurrences in double-positive (real-time PCR oral and gastric infection) patients. Oral hygiene involved mouthwash with neutral electrolyzed water (NEW), with or without periodontal treatment. One hundred patients were equally distributed into four groups: NS, NS-PT, NEW, and NEW-PT. All patients had concomitant systemic therapy and additionally, the following oral treatments: mouthwash with normal saline (NS), periodontal treatment and mouthwash with normal saline (NS-PT), mouthwash with NEW (NEW), and periodontal treatment and mouthwash with NEW (NEW-PT). Gastric and oral infection and symptoms were evaluated one and four months after treatments.

Results

Integral therapy with NEW-PT increased gastric eradication rates compared with NS or NS-PT (84%−96% vs. 20%−56%; p < 0.001). Even more, a protective effect of 81.2% (RR = 0.1877; 95% CI: 0.0658−0.5355; p = 0.0018) against recurrences and 76.6% (RR = 0.2439; 95% CI: 0.1380−0.4310; p < 0.001) against treatment failure (eradication of infection and associated symptoms) was observed in patients from the NEW and NEW-PT groups.

Conclusions

Implementation of oral hygiene and systemic treatment can increase the eradication of gastric infection, associated symptoms, and recurrences. NEW is recommended as an antiseptic mouthwash due to its efficacy and short- and long-term safety.

Abstract Image

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用中性电解水进行口腔卫生和系统治疗可提高胃幽门螺旋杆菌的根除率并减少复发。

目的：幽门螺杆菌胃感染与慢性胃炎、功能性消化不良等胃病以及消化性溃疡和胃癌等并发症密切相关。在发展中国家，由于抗生素耐药性的增加，系统治疗通常并不成功。此外，口腔幽门螺杆菌感染和牙周病也与胃病治疗失败有关。本研究旨在探讨综合疗法（包括口腔卫生和同时进行的系统治疗）对提高根除胃部感染和复发率的效果：进行了一项前瞻性、随机、四臂、平行组、开放标签临床试验，研究综合疗法对根除胃幽门螺杆菌感染和避免双阳性（实时 PCR 口腔和胃感染）患者复发的疗效。口腔卫生包括使用中性电解水（NEW）漱口，同时进行或不进行牙周治疗。100 名患者平均分为四组：NS组、NS-PT组、NEW组和NEW-PT组。所有患者在接受全身治疗的同时，还接受了以下口腔治疗：用生理盐水漱口（NS）、牙周治疗和用生理盐水漱口（NS-PT）、用中性电解水漱口（NEW）和牙周治疗和用中性电解水漱口（NEW-PT）。治疗后一个月和四个月对胃部和口腔感染及症状进行评估：结果：与 NS 或 NS-PT 相比，NEW-PT 综合疗法提高了胃部根除率（84%-96% vs. 20%-56%; p 结论：口腔卫生和全身治疗的实施可提高胃部根除率（84%-96% vs. 20%-56%; p）：实施口腔卫生和全身治疗可提高胃感染、相关症状和复发的根除率。由于其疗效以及短期和长期的安全性，推荐使用 NEW 作为消毒漱口水。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Dental Research DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.30

自引率

5.60%

发文量

165

审稿时长

26 weeks

期刊介绍： Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.