RAGging on recombination signal sequence strength for diffusion-mediated recombination

IF 3.2 4区医学 Q3 CELL BIOLOGY

Immunology & Cell Biology Pub Date : 2024-07-07 DOI:10.1111/imcb.12803

Katherine JL Jackson

引用次数: 0

Abstract

In this article, we discuss new insights into the distinct mechanisms for V(D)J recombination for different immunoglobulin loci. This follows the recent revelation that recombination signal sequences (RSS) within the IGKV locus have evolved to be more efficient mediators of recombination activating gene (RAG) recombination compared to the same elements in the IGH locus. This difference in RSS strength is proposed to be driven by different molecular mechanisms for RAG-mediated recombination between the two loci.

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对扩散介导重组的重组信号序列强度进行 RAGging。

在这篇文章中，我们讨论了不同免疫球蛋白基因座的 V(D)J 重组不同机制的新见解。这是继最近发现 IGKV 基因座中的重组信号序列（RSS）与 IGH 基因座中的相同元件相比，已进化为更有效的重组激活基因（RAG）重组介质之后的又一发现。这种 RSS 强度的差异被认为是由两个基因座之间 RAG 介导的重组的不同分子机制驱动的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology & Cell Biology 医学-免疫学

CiteScore

7.50

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The Australasian Society for Immunology Incorporated (ASI) was created by the amalgamation in 1991 of the Australian Society for Immunology, formed in 1970, and the New Zealand Society for Immunology, formed in 1975. The aim of the Society is to encourage and support the discipline of immunology in the Australasian region. It is a broadly based Society, embracing clinical and experimental, cellular and molecular immunology in humans and animals. The Society provides a network for the exchange of information and for collaboration within Australia, New Zealand and overseas. ASI members have been prominent in advancing biological and medical research worldwide. We seek to encourage the study of immunology in Australia and New Zealand and are active in introducing young scientists to the discipline.