Friction between a single platelet and fibrinogen

IF 6.3 1区 工程技术 Q1 ENGINEERING, MECHANICAL
Friction Pub Date : 2024-07-06 DOI:10.1007/s40544-024-0886-3
Yuhe Wang, Yan Li, Shuguang Zhang, Haosheng Chen, Yongjian Li
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引用次数: 0

Abstract

Friction has been considered to mediate physiological activities of cells, however, the biological friction between a single cell and its ligand-bound surface has not been thoroughly explored. Herein, we established a friction model for single cells based on an atomic force microscopy (AFM) combined with an inverted fluorescence microscopy (IFM) to study the friction between a highly sensitive platelet and fibrinogen-coated surface. The study revealed that the friction between the platelet and fibrinogen-coated tip is mainly influenced by specific ligand–receptor interaction. Further, we modeled the biological friction, which consists of specific interaction, non-specific interaction, and mechanical effect. Besides, the results suggested that the velocity can also affect specific ligand–receptor interactions, resulting in the friction change and platelet adhesion to fibrinogen surfaces. The study built a friction model between a single cell and its ligand-bound surface and provided a potential method to study the biological friction by the combination of AFM and IFM.

Abstract Image

单个血小板与纤维蛋白原之间的摩擦力
摩擦一直被认为是细胞生理活动的介导因素,然而,单细胞与其配体结合表面之间的生物摩擦尚未得到深入探讨。在此,我们基于原子力显微镜(AFM)结合倒置荧光显微镜(IFM)建立了单细胞摩擦模型,研究了高灵敏度血小板与纤维蛋白原涂层表面之间的摩擦。研究发现,血小板与纤维蛋白原涂层尖端之间的摩擦主要受特定配体-受体相互作用的影响。此外,我们还建立了生物摩擦模型,其中包括特异性相互作用、非特异性相互作用和机械效应。此外,研究结果表明,速度也会影响配体与受体之间的特异性相互作用,从而导致摩擦力的变化和血小板对纤维蛋白原表面的粘附。该研究建立了单细胞与其配体结合表面之间的摩擦模型,为结合原子力显微镜和原子力显微镜研究生物摩擦提供了一种可能的方法。
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来源期刊
Friction
Friction Engineering-Mechanical Engineering
CiteScore
12.90
自引率
13.20%
发文量
324
审稿时长
13 weeks
期刊介绍: Friction is a peer-reviewed international journal for the publication of theoretical and experimental research works related to the friction, lubrication and wear. Original, high quality research papers and review articles on all aspects of tribology are welcome, including, but are not limited to, a variety of topics, such as: Friction: Origin of friction, Friction theories, New phenomena of friction, Nano-friction, Ultra-low friction, Molecular friction, Ultra-high friction, Friction at high speed, Friction at high temperature or low temperature, Friction at solid/liquid interfaces, Bio-friction, Adhesion, etc. Lubrication: Superlubricity, Green lubricants, Nano-lubrication, Boundary lubrication, Thin film lubrication, Elastohydrodynamic lubrication, Mixed lubrication, New lubricants, New additives, Gas lubrication, Solid lubrication, etc. Wear: Wear materials, Wear mechanism, Wear models, Wear in severe conditions, Wear measurement, Wear monitoring, etc. Surface Engineering: Surface texturing, Molecular films, Surface coatings, Surface modification, Bionic surfaces, etc. Basic Sciences: Tribology system, Principles of tribology, Thermodynamics of tribo-systems, Micro-fluidics, Thermal stability of tribo-systems, etc. Friction is an open access journal. It is published quarterly by Tsinghua University Press and Springer, and sponsored by the State Key Laboratory of Tribology (TsinghuaUniversity) and the Tribology Institute of Chinese Mechanical Engineering Society.
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