Aleksei A. Popov, Irina O. Petruseva, Olga I. Lavrik
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引用次数: 0
Abstract
Damages of various origin accumulated in the genomic DNA can lead to the breach of genome stability, and are considered to be one of the main factors involved in cellular senescence. DNA repair systems in mammalian cells ensure effective damage removal and repair of the genome structure, therefore, activity of these systems is expected to be correlated with high maximum lifespan observed in the long-lived mammals. This review discusses current results of the studies focused on determination of the DNA repair system activity and investigation of the properties of its key regulatory proteins in the cells of long-lived rodents and bats. Based on the works discussed in the review, it could be concluded that the long-lived rodents and bats in general demonstrate high efficiency in functioning and regulation of DNA repair systems. Nevertheless, a number of questions around the study of DNA repair in the cells of long-lived rodents and bats remain poorly understood, answers to which could open up new avenues for further research.
摘要 基因组 DNA 中积累的各种来源的损伤会导致基因组稳定性受到破坏,被认为是细胞衰老的主要因素之一。哺乳动物细胞中的 DNA 修复系统可确保有效清除损伤和修复基因组结构,因此,这些系统的活性预计与长寿哺乳动物的最长寿命相关。这篇综述讨论了目前的研究成果,这些研究的重点是确定 DNA 修复系统的活性以及调查长寿啮齿动物和蝙蝠细胞中其关键调控蛋白的特性。根据综述中讨论的工作,可以得出结论:长寿啮齿类动物和蝙蝠在 DNA 修复系统的运作和调节方面普遍表现出很高的效率。尽管如此,围绕长寿啮齿类动物和蝙蝠细胞中 DNA 修复研究的一些问题仍然鲜为人知,这些问题的答案将为进一步的研究开辟新的途径。
期刊介绍:
Biochemistry (Moscow) is the journal that includes research papers in all fields of biochemistry as well as biochemical aspects of molecular biology, bioorganic chemistry, microbiology, immunology, physiology, and biomedical sciences. Coverage also extends to new experimental methods in biochemistry, theoretical contributions of biochemical importance, reviews of contemporary biochemical topics, and mini-reviews (News in Biochemistry).