Bredigite Bioceramic: A Promising Candidate for Bone Tissue Engineering

IF 2.8 3区材料科学 Q3 CHEMISTRY, PHYSICAL

Silicon Pub Date : 2024-07-05 DOI:10.1007/s12633-024-03083-9

Mohammad Khodaei, Akram Nadi

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引用次数: 0

Abstract

Because of their desirable characteristics, ceramic-based scaffolds have emerged as prominent candidates for artificial bone replacements in bone regeneration procedures. Bredigite (Ca₇MgSi₄O₁₆) ceramic has demonstrated favorable bioactivity, bone growth, and mechanical qualities, making it a viable candidate for replacing bone defects. This review presents the main techniques employed for the synthesis of bredigite. It was also mentioned how combining bredigite ceramic with other materials might increase the quality of composites. Because of the presence of magnesium in bredigite, it has higher mechanical properties and chemical stability than calcium silicates such as wollastonite, dicalcium silicate, and tricalcium silicate. The density and elastic modulus of bredigite is 3.4 gr/cm3 and 43 GPa, respectively. Higher mechanical properties of bredigite compared to polymers, and its biocompatibility, bioactivity, and osteoconductivity, can cause to higher quality of polymer-bredigite composite than that of polymer. Based on findings derived from many investigations conducted in in-vitro and in-vivo contexts, bredigite has great promise as a flexible and efficient material for bone tissue engineering. Additional research is needed to maximize the clinical applications of bredigite bioceramics.

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Bredigite 生物陶瓷：骨组织工程的理想候选材料

陶瓷基支架因其理想的特性，已成为骨再生手术中人工骨替代物的主要候选材料。红柱石（Ca7MgSi4O16）陶瓷具有良好的生物活性、骨生长和机械性能，是替代骨缺损的可行候选材料。本综述介绍了合成红柱石的主要技术。此外，还提到了将红柱石陶瓷与其他材料结合可提高复合材料的质量。由于红柱石中含有镁，因此与硅灰石、硅酸二钙和硅酸三钙等硅酸钙相比，红柱石具有更高的机械性能和化学稳定性。红柱石的密度和弹性模量分别为 3.4 gr/cm3 和 43 GPa。与聚合物相比，红柱石具有更高的机械性能，其生物相容性、生物活性和骨传导性可使聚合物-红柱石复合材料的质量高于聚合物。根据在体外和体内进行的多项研究结果，红柱石作为一种灵活高效的骨组织工程材料大有可为。要想最大限度地提高红柱石生物陶瓷的临床应用价值，还需要进行更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Silicon CHEMISTRY, PHYSICAL-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

5.90

自引率

20.60%

发文量

685

审稿时长

>12 weeks

期刊介绍： The journal Silicon is intended to serve all those involved in studying the role of silicon as an enabling element in materials science. There are no restrictions on disciplinary boundaries provided the focus is on silicon-based materials or adds significantly to the understanding of such materials. Accordingly, such contributions are welcome in the areas of inorganic and organic chemistry, physics, biology, engineering, nanoscience, environmental science, electronics and optoelectronics, and modeling and theory. Relevant silicon-based materials include, but are not limited to, semiconductors, polymers, composites, ceramics, glasses, coatings, resins, composites, small molecules, and thin films.