Circuit dynamics of the olfactory pathway during olfactory learning

IF 3.4 3区医学 Q2 NEUROSCIENCES

Frontiers in Neural Circuits Pub Date : 2024-07-05 DOI:10.3389/fncir.2024.1437575

Yutian J. Zhang, Jason Y. Lee, Kei M. Igarashi

引用次数: 0

Abstract

The olfactory system plays crucial roles in perceiving and interacting with their surroundings. Previous studies have deciphered basic odor perceptions, but how information processing in the olfactory system is associated with learning and memory is poorly understood. In this review, we summarize recent studies on the anatomy and functional dynamics of the mouse olfactory learning pathway, focusing on how neuronal circuits in the olfactory bulb (OB) and olfactory cortical areas integrate odor information in learning. We also highlight in vivo evidence for the role of the lateral entorhinal cortex (LEC) in olfactory learning. Altogether, these studies demonstrate that brain regions throughout the olfactory system are critically involved in forming and representing learned knowledge. The role of olfactory areas in learning and memory, and their susceptibility to dysfunction in neurodegenerative diseases, necessitate further research.

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嗅觉学习过程中嗅觉通路的回路动力学

嗅觉系统在感知周围环境并与之互动方面发挥着至关重要的作用。以往的研究已经破译了基本的气味感知，但对嗅觉系统的信息处理如何与学习和记忆相关却知之甚少。在这篇综述中，我们总结了关于小鼠嗅觉学习通路的解剖和功能动态的最新研究，重点是嗅球（OB）和嗅觉皮层区域的神经元回路如何在学习中整合气味信息。我们还强调了外侧内嗅皮层（LEC）在嗅觉学习中作用的体内证据。总之，这些研究表明，整个嗅觉系统的脑区在形成和表征所学知识方面发挥着至关重要的作用。嗅觉区域在学习和记忆中的作用，以及它们在神经退行性疾病中易出现的功能障碍，都需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Neural Circuits NEUROSCIENCES-

CiteScore

6.00

自引率

5.70%

发文量

135

审稿时长

4-8 weeks

期刊介绍： Frontiers in Neural Circuits publishes rigorously peer-reviewed research on the emergent properties of neural circuits - the elementary modules of the brain. Specialty Chief Editors Takao K. Hensch and Edward Ruthazer at Harvard University and McGill University respectively, are supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics and the public worldwide. Frontiers in Neural Circuits launched in 2011 with great success and remains a "central watering hole" for research in neural circuits, serving the community worldwide to share data, ideas and inspiration. Articles revealing the anatomy, physiology, development or function of any neural circuitry in any species (from sponges to humans) are welcome. Our common thread seeks the computational strategies used by different circuits to link their structure with function (perceptual, motor, or internal), the general rules by which they operate, and how their particular designs lead to the emergence of complex properties and behaviors. Submissions focused on synaptic, cellular and connectivity principles in neural microcircuits using multidisciplinary approaches, especially newer molecular, developmental and genetic tools, are encouraged. Studies with an evolutionary perspective to better understand how circuit design and capabilities evolved to produce progressively more complex properties and behaviors are especially welcome. The journal is further interested in research revealing how plasticity shapes the structural and functional architecture of neural circuits.