Bibrita Bhar, Rajan Singh, Vaishak Kundudi Ramesh, Souradeep Dey, Samit K. Nandi, Roy Paily, Biman B. Mandal
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引用次数: 0
Abstract
Skin wound healing is a highly orchestrated and complex dynamic process, presenting a significant healthcare challenge when its natural progression is interrupted. Despite the known effectiveness of electrical stimulation (ES) in aiding wound recovery, its practical application remains limited by the use of large complicated equipment. Here, we present a miniaturized wearable electroceutical platform (WEP) that generates low-intensity electrical pulses, which are transmitted to the wound site via a breathable electrical bandage patch through a silk-based antimicrobial ionogel interface. In vivo efficacy assessment of WEP demonstrated a significantly rapid wound closure. Histological and immunostaining analysis exhibited accelerated granulation tissue formation, extracellular matrix (ECM) remodeling, and re-epithelization in the presence of pulsed ES. In vitro studies showed ES-facilitated changes in fibroblast response, including proliferation, alignment, and ECM secretion, which potentially contributed to the observed improvements in the healing process. The developed WEP possesses great translational potential, offering an advanced cost-effective therapeutic solution for wound care.
期刊介绍:
ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.