Physician visits for psoriasis and reduced risk of adverse pregnancy outcomes: A nationwide study in Taiwan

IF 2.3 4区 医学 Q2 DERMATOLOGY
Li-Ting Kao, Hui-Wen Yang, Yu-Tien Chang, I-Hsun Li, Liang-Hsuan Chen, Ya-Chiao Hu, Yi-Hsien Chen
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Abstract

Background: 

It is unclear whether women with psoriasis who receive adequate management or achieve better control of their psoriasis before and during pregnancy could eliminate the negative effects.

Objectives: 

The objective of this study was to investigate the association between physician visits for psoriasis and adverse pregnancy outcomes.

Methods: 

This study used the National Health Insurance database and Birth Certificate Application in Taiwan. This research further categorized the study subjects into mothers with mild/severe psoriasis who visited physicians for psoriasis before delivery, mothers with mild/severe psoriasis who did not visit a physician for psoriasis before delivery, and mothers without psoriasis. Logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) for the occurrence of adverse pregnancy outcomes, including maternal and neonatal outcomes.

Results: 

3,339 mothers with severe psoriasis, 41,296 mothers with mild psoriasis, and 2,017,271 mothers without psoriasis were included in this study. The mothers with mild/severe psoriasis demonstrated a significantly higher risk of labor complications and maternal risk factors. After adjusting for confounders, mothers with severe psoriasis who did not visit a physician for psoriasis demonstrated significantly higher odds of labor complications (OR 1.217), maternal risk factors (OR 1.507), having low-birth weight infants (OR 1.236), etc., than mothers without psoriasis.

Conclusion: 

This study demonstrated that mothers with psoriasis had a higher risk of adverse pregnancy outcomes. In addition, seeking medical care for psoriasis, particularly for women with severe psoriasis, appeared to exert a protective effect against adverse pregnancy outcomes.

银屑病就诊与降低不良妊娠结局风险:台湾一项全国性研究
背景:目前尚不清楚患有银屑病的妇女在怀孕前和怀孕期间接受适当的治疗或更好地控制银屑病是否能消除其负面影响:本研究旨在调查银屑病就诊与不良妊娠结局之间的关联:本研究使用了台湾的国民健康保险数据库和出生证明申请表。本研究进一步将研究对象分为分娩前曾就诊的轻度/重度银屑病母亲、分娩前未就诊的轻度/重度银屑病母亲和无银屑病母亲。采用逻辑回归法计算不良妊娠结局(包括孕产妇和新生儿结局)发生的几率比(ORs)和95%置信区间(CIs):本研究共纳入 3,339 名重度银屑病母亲、41,296 名轻度银屑病母亲和 2,017,271 名无银屑病母亲。患有轻度/重度银屑病的母亲出现分娩并发症的风险明显较高,产妇风险因素也较高。在对混杂因素进行调整后,患有重度银屑病但未因银屑病就医的母亲出现分娩并发症(OR 1.217)、孕产妇风险因素(OR 1.507)、低体重儿(OR 1.236)等的几率明显高于无银屑病的母亲:本研究表明,患有银屑病的母亲发生不良妊娠结局的风险更高。此外,银屑病就医,尤其是患有严重银屑病的妇女,似乎对不良妊娠结局有保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Dermatologica Sinica
Dermatologica Sinica DERMATOLOGY-
CiteScore
2.80
自引率
20.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Dermatologica Sinica aims to publish high quality scientific research in the field of dermatology, with the goal of promoting and disseminating dermatological-related medical science knowledge to improve global health. Articles on clinical, laboratory, educational, and social research in dermatology and other related fields that are of interest to the medical profession are eligible for consideration. Review articles, original articles, brief reports, case reports and correspondence are accepted.
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