Chemical Compositions, Antimicrobial and Therapeutic Properties of Essential Oils of Dennettia Tripetala

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-04 DOI:10.2174/0115734110313735240624074507

Ekandem Joachim J., Udourioh Godwin A., Obi Leonard K., Moses M. Solomon

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Abstract

Background: It is well-known that essential oils are a rich source of bioactive components and are traditionally used as one of the alternatives to conventional medicines for treating various diseases and symptoms. Like other natural products, they are safe but should be used with care since all substances have potential toxicity depending on the conditions of exposure, the dose, and the route of administration. Method: This manuscript studies the chemical composition and antimicrobial properties of essential oil derived from D. tripetala. The essential oil was extracted from fresh D. tripetala fruits using steam distillation and subsequently subjected to Fourier Transform Infrared Spectroscopy (FT-IR) and Gas Chromatography with Flame Ionization detection (GC-FID) analyses. The antimicrobial potential of the essential oil was evaluated against a panel of microorganisms, namely Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhi, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans, and Aspergillus niger. Results: The GC-FID analysis unveiled a diverse array of compounds within the essential oil, with the notable constituents being linalool, benzyl nitrile, benzene (2-nitroethyl), bicyclo(4.2.0)octa1,3,5-triene, 1,3,7-Octatrien-5-yne, styrene, butylated hydroxytoluene, and Nerolidol 2. D. tripetala essential oil significantly inhibits the microbial activities of all the tested organisms. It exhibits inhibitory activity against Bacillus subtilis and Escherichia coli at a MIC value of 12.5%, Staphylococcus aureus, and Pseudomonas aeruginosa at a MIC value of 25%, Candida albicans at a MIC value of 50%, and Aspergillus niger at MIC value 25%. The strongest inhibition of the oil is against Klebsiella pneumoniae at a MIC value of 3.12%. Conclusion: This research posits that the ethnomedicinal value ascribed to the essential oil of D. tripetala can be attributed to the presence of the identified compounds, some of which are already recognized for their biological activities. The essential oil presents promising potential as a source of lead compounds for developing anti-infective drugs, particularly those targeted against Klebsiella pneumoniae

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Dennettia Tripetala 精油的化学成分、抗菌和治疗特性

背景：众所周知，精油含有丰富的生物活性成分，传统上被用作治疗各种疾病和症状的传统药物替代品之一。与其他天然产品一样，精油是安全的，但在使用时应小心谨慎，因为所有物质都有潜在的毒性，这取决于接触的条件、剂量和给药途径。研究方法本手稿研究了从 D. tripetala 提取的精油的化学成分和抗菌特性。精油采用蒸汽蒸馏法从新鲜的三叶木果中提取，然后进行傅立叶变换红外光谱（FT-IR）和气相色谱-火焰离子化检测（GC-FID）分析。评估了精油对金黄色葡萄球菌、枯草杆菌、大肠杆菌、伤寒沙门氏菌、肺炎克雷伯菌、绿脓杆菌、白色念珠菌和黑曲霉等微生物的抗菌潜力。结果GC-FID 分析揭示了精油中的多种化合物，主要成分有芳樟醇、苄基腈、苯（2-硝基乙基）、双环（4.2.0）辛-1,3,5-三烯、1,3,7-辛三烯-5-炔、苯乙烯、丁基羟基甲苯和橙花叔醇 2。三叶草精油对所有受测微生物的活性都有明显的抑制作用。它对枯草杆菌和大肠杆菌的抑制活性为 MIC 值的 12.5%，对金黄色葡萄球菌和绿脓杆菌的抑制活性为 MIC 值的 25%，对白色念珠菌的抑制活性为 MIC 值的 50%，对黑曲霉的抑制活性为 MIC 值的 25%。该精油对肺炎克雷伯菌的抑制作用最强，其 MIC 值为 3.12%。结论这项研究认为，D. tripetala 精油的民族药用价值可归因于其中已确定的化合物，其中一些化合物的生物活性已得到认可。该精油有望成为开发抗感染药物的先导化合物来源，尤其是针对肺炎克雷伯氏菌的药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.