Serial paired arterial and jugular venous point-of-care values in dogs undergoing manual basic life support

IF 1.1 3区农林科学 Q3 VETERINARY SCIENCES

Journal of veterinary emergency and critical care Pub Date : 2024-07-07 DOI:10.1111/vec.13406

Sabrina N. Hoehne Dr med vet, DACVECC, DECVECC, Kate Hopper BVSc, PhD, DACVECC, Marlis L. Rezende DVM, PhD, DACVAA, Angela Borchers Dr med vet, DVM, DACVIM, DACVECC, Steven E. Epstein DVM, DACVECC

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引用次数: 0

Abstract

Objective

To evaluate differences in point-of-care (POC) variables obtained from arterial and jugular venous blood in dogs undergoing manual basic life support (BLS) and report changes over time.

Design

Experimental study.

Setting

Small animal research facility.

Animals

Twenty-four purpose-bred research dogs.

Interventions

Dogs were anesthetized, and arterial catheters were placed before euthanasia. One minute after cardiopulmonary arrest, BLS consisting of manual chest compressions and ventilation delivered via endotracheal intubation, face mask, mouth-to-nose, or no ventilation was initiated. Paired arterial and jugular venous blood samples were obtained for POC testing before euthanasia (T₀), at 3 minutes (T₃), and at 6 minutes (T₆) into BLS.

Measurements and Main Results

The association of POC variables with arterial or venous sample type while controlling for type of ventilation and sampling timepoint was determined using a generalized linear mixed model. Variables obtained from arterial and venous blood samples were compared over time using repeated measures ANOVA or Friedman test. Pao₂, anion gap, potassium, chloride, glucose concentration, and PCV were significantly higher in arterial blood samples compared with venous samples (P < 0.03). By T₆, arterial glucose concentration, arterial and venous base excess, venous pH, and plasma lactate, potassium, creatinine, bicarbonate, and sodium concentrations were significantly increased, and arterial and venous Po₂, ionized calcium concentration, PCV, and total plasma protein concentration were significantly decreased from T₀ (P < 0.05).

Conclusions

Although statistically significant, arteriovenous differences and changes in POC blood variables during BLS were small and not clinically relevant over time. Given the challenges of arterial blood sampling, it may be reasonable to pursue venous blood sampling during CPR. Further studies in dogs undergoing BLS and advanced life support are needed to better understand the potential clinical role of POC testing during CPR.

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接受人工基本生命支持的狗的连续配对动脉和颈静脉护理点数值。

目的评估从接受人工基本生命支持（BLS）的狗的动脉和颈静脉血液中获取的护理点（POC）变量的差异，并报告随时间推移发生的变化：设计：实验研究：环境：小型动物研究机构：24只专门饲养的研究犬：对狗进行麻醉，并在安乐死前放置动脉导管。心肺骤停一分钟后，启动 BLS，包括人工胸外按压和通过气管插管、面罩、口对鼻或不通气进行通气。在安乐死前（T0）、BLS 开始 3 分钟（T3）和 6 分钟（T6）时采集配对动脉血和颈静脉血样本进行 POC 测试：在控制通气类型和采样时间点的同时，使用广义线性混合模型确定 POC 变量与动脉或静脉样本类型的关联。使用重复测量方差分析或弗里德曼检验比较了动脉血样本和静脉血样本随时间变化的变量。动脉血样本中的 Pao2、阴离子间隙、钾、氯化物、葡萄糖浓度和 PCV 均显著高于静脉血样本（P.6），动脉葡萄糖浓度、动脉和静脉碱过量、静脉 pH 值和血浆乳酸盐、钾、肌酐、碳酸氢盐和钠浓度显著升高，动脉和静脉 Po2、离子钙浓度、PCV 和血浆总蛋白浓度较 T0 显著降低（P 结论：动脉和静脉血样本中的 Pao2、阴离子间隙、钾、氯化物、葡萄糖浓度和 PCV 均显著高于静脉血样本（P.7）：尽管具有统计学意义，但 BLS 期间动静脉差异和 POC 血液变量的变化较小，且随着时间的推移与临床无关。考虑到动脉血采样的困难，在心肺复苏期间进行静脉血采样可能是合理的。要更好地了解心肺复苏期间 POC 检测的潜在临床作用，还需要对接受 BLS 和高级生命支持的狗进行进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of veterinary emergency and critical care 农林科学-兽医学

CiteScore

2.50

自引率

15.40%

发文量

121

审稿时长

18-36 weeks

期刊介绍： The Journal of Veterinary Emergency and Critical Care’s primary aim is to advance the international clinical standard of care for emergency/critical care patients of all species. The journal’s content is relevant to specialist and non-specialist veterinarians practicing emergency/critical care medicine. The journal achieves it aims by publishing descriptions of unique presentation or management; retrospective and prospective evaluations of prognosis, novel diagnosis, or therapy; translational basic science studies with clinical relevance; in depth reviews of pertinent topics; topical news and letters; and regular themed issues. The journal is the official publication of the Veterinary Emergency and Critical Care Society, the American College of Veterinary Emergency and Critical Care, the European Veterinary Emergency and Critical Care Society, and the European College of Veterinary Emergency and Critical Care. It is a bimonthly publication with international impact and adheres to currently accepted ethical standards.