From long-term to short-term: Distinct neural networks underlying semantic knowledge and its recruitment in working memory

Abstract

Although numerous studies suggest that working memory (WM) and semantic long-term knowledge interact, the nature and underlying neural mechanisms of this intervention remain poorly understood. Using functional magnetic resonance imaging (fMRI), this study investigated the extent to which neural markers of semantic knowledge in long-term memory (LTM) are activated during the WM maintenance stage in 32 young adults. First, the multivariate neural patterns associated with four semantic categories were determined via an implicit semantic activation task. Next, the participants maintained words – the names of the four semantic categories implicitly activated in the first task – in a verbal WM task. Multi-voxel pattern analyses showed reliable neural decoding of the four semantic categories in the implicit semantic activation and the verbal WM tasks. Critically, however, no between-task classification of semantic categories was observed. Searchlight analyses showed that for the WM task, semantic category information could be decoded in anterior temporal areas associated with abstract semantic category knowledge. In the implicit semantic activation task, semantic category information was decoded in superior temporal, occipital and frontal cortices associated with domain-specific semantic feature representations. These results indicate that item-level semantic activation during verbal WM involves shallow rather than deep semantic information.