Hydroxyurea in Sickle Cell Disease and Invasive Bacterial Infections: A Case-Control Study.

IF 2.5 4区医学 Q3 INFECTIOUS DISEASES

Journal of the Pediatric Infectious Diseases Society Pub Date : 2024-09-26 DOI:10.1093/jpids/piae071

Alice Pascault, Bérengère Koehl, Valentine Brousse, Malika Benkerrou, Jean Gaschignard

引用次数: 0

Abstract

Hydroxyurea decreases painful events among children with sickle cell disease (SCD) but could increase the risk of infections in treated patients through leucopenia. We performed a case-control study, comparing hydroxyurea treatment for SCD in cases with an invasive bacterial infection and in controls without infection. No difference was found.

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镰状细胞病中的羟基脲与侵袭性细菌感染：一项病例对照研究。

羟基脲可减少镰状细胞病患儿的疼痛，但会因白细胞减少而增加患者感染的风险。我们进行了一项病例对照研究，比较了使用羟基脲治疗镰状细胞病时感染侵入性细菌的病例和未感染的对照组。结果未发现差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Pediatric Infectious Diseases Society Medicine-Pediatrics, Perinatology and Child Health

CiteScore

6.70

自引率

0.00%

发文量

179

期刊介绍： The Journal of the Pediatric Infectious Diseases Society (JPIDS), the official journal of the Pediatric Infectious Diseases Society, is dedicated to perinatal, childhood, and adolescent infectious diseases. The journal is a high-quality source of original research articles, clinical trial reports, guidelines, and topical reviews, with particular attention to the interests and needs of the global pediatric infectious diseases communities.