The Society for Cardiovascular Magnetic Resonance Registry at 150,000.

IF 4.2 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Magnetic Resonance Pub Date : 2024-07-04 DOI:10.1016/j.jocmr.2024.101055

Matthew S Tong, Jeremy A Slivnick, Behzad Sharif, Han W Kim, Alistair A Young, Lilia M Sierra-Galan, Kanae Mukai, Afshin Farzaneh-Far, Sadeer Al-Kindi, Angel T Chan, George Dibu, Michael D Elliott, Vanessa M Ferreira, John Grizzard, Sebastian Kelle, Simon Lee, Maan Malahfji, Steffen E Petersen, Venkateshwar Polsani, Olga H Toro-Salazar, Kamran A Shaikh, Chetan Shenoy, Monvadi B Srichai, Jadranka Stojanovska, Qian Tao, Janet Wei, Jonathan W Weinsaft, W Benjamin Wince, Priya D Chudgar, Matthew Judd, Robert M Judd, Dipan J Shah, Orlando P Simonetti

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引用次数: 0

Abstract

Background: Cardiovascular magnetic resonance (CMR) is increasingly utilized to evaluate expanding cardiovascular conditions. The Society for Cardiovascular Magnetic Resonance (SCMR) Registry is a central repository for real-world clinical data to support cardiovascular research, including those relating to outcomes, quality improvement, and machine learning. The SCMR Registry is built on a regulatory-compliant, cloud-based infrastructure that houses searchable content and Digital Imaging and Communications in Medicine images. The goal of this study is to summarize the status of the SCMR Registry at 150,000 exams.

Methods: The processes for data security, data submission, and research access are outlined. We interrogated the Registry and presented a summary of its contents.

Results: Data were compiled from 154,458 CMR scans across 20 United States sites, containing 299,622,066 total images (∼100 terabytes of storage). Across reported values, the human subjects had an average age of 58 years (range 1 month to >90 years old), were 44% (63,070/145,275) female, 72% (69,766/98,008) Caucasian, and had a mortality rate of 8% (9,962/132,979). The most common indication was cardiomyopathy (35,369/131,581, 27%), and most frequently used current procedural terminology code was 75561 (57,195/162,901, 35%). Macrocyclic gadolinium-based contrast agents represented 89% (83,089/93,884) of contrast utilization after 2015. Short-axis cines were performed in 99% (76,859/77,871) of tagged scans, short-axis late gadolinium enhancement (LGE) in 66% (51,591/77,871), and stress perfusion sequences in 30% (23,241/77,871). Mortality data demonstrated increased mortality in patients with left ventricular ejection fraction <35%, the presence of wall motion abnormalities, stress perfusion defects, and infarct LGE, compared to those without these markers. There were 456,678 patient-years of all-cause mortality follow-up, with a median follow-up time of 3.6 years.

Conclusion: The vision of the SCMR Registry is to promote evidence-based utilization of CMR through a collaborative effort by providing a web mechanism for centers to securely upload de-identified data and images for research, education, and quality control. The Registry quantifies changing practice over time and supports large-scale real-world multicenter observational studies of prognostic utility.

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心血管磁共振学会注册人数为 15 万。

摘要背景：心血管磁共振（CMR）越来越多地被用于评估不断扩大的心血管疾病：背景：心血管磁共振（CMR）越来越多地被用于评估不断扩大的心血管疾病。SCMR 注册中心是真实世界临床数据的中央存储库，用于支持心血管研究，包括与结果、质量改进和机器学习相关的研究。SCMR 注册中心建立在一个符合法规要求、基于云的基础架构上，其中包含可搜索内容和医学数字成像和通信（DICOM）图像：方法：概述了数据安全、数据提交和研究访问的流程。方法：概述了数据安全、数据提交和研究访问的流程。我们对注册中心进行了询问，并对其内容进行了总结：数据来自美国 20 个站点的 154,458 次 CMR 扫描，共包含 299,622,066 张图像（约 100 TB 的存储空间）。受试者的平均年龄为 58 岁（从 1 个月到超过 90 岁不等），44% 为女性，72% 为白种人，死亡率为 8%。最常见的适应症是心肌病（27%），最常用的现行程序术语（CPT）代码是 75561（35%）。2015年后，大环钆类造影剂占造影剂使用量的89%。99%的扫描使用了短轴Cines，66%的扫描使用了短轴LGE，30%的扫描使用了应激灌注序列。死亡率数据显示，左室射血分数（LVEF）小于35%、存在室壁运动异常、应激灌注缺陷和梗死晚期钆增强（LGE）的患者死亡率高于无这些标记物的患者。对456,678名患者进行了全因死亡率随访，中位随访时间为3.6年：SCMR 注册中心的愿景是通过合作努力，为各中心提供一个网络机制，安全上传用于研究、教育和质量控制的去标识化数据和图像，从而促进以证据为基础的 CMR 利用。该注册中心可量化随时间推移而不断变化的实践，并支持对预后效用进行大规模真实世界多中心观察研究。精简摘要：SCMR 注册中心是一个符合法规要求的中央云端存储库，用于多中心心血管研究的真实世界临床数据和 DICOM 图像，包括基于结果的数据。注册中心包含 299,622,066 张 DICOM 图像和 456,678 个患者随访年。来自美国 20 个站点的 154,458 次 CMR 扫描的数据显示，心肌病是最常见的适应症，2015 年后大环内酯钆对比剂的使用率达到 89%。总死亡率为 8%，其中 LVEF 较高的患者死亡率较高。

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来源期刊

Journal of Cardiovascular Magnetic Resonance 医学-核医学

CiteScore

10.90

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to: New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system. New methods to enhance or accelerate image acquisition and data analysis. Results of multicenter, or larger single-center studies that provide insight into the utility of CMR. Basic biological perceptions derived by CMR methods.