Association between depression and incident dementia: Longitudinal findings from the share study

IF 3.6 3区医学 Q2 GERIATRICS & GERONTOLOGY

International Journal of Geriatric Psychiatry Pub Date : 2024-07-05 DOI:10.1002/gps.6121

Nicola Veronese, Lee Smith, Ai Koyanagi, Pinar Soysal, Christopher Mueller, Chiara Maria Errera, Giusy Vassallo, Laura Vernuccio, Giuseppina Catanese, Marco Solmi, Ligia J. Dominguez, Mario Barbagallo

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引用次数: 0

Abstract

Background

The association between depression and dementia is still unclear, particularly regarding depression as a potential risk factor preceding dementia. Therefore, we aimed to verify if the presence of depression at baseline may increase the risk of dementia and cognitive impairment during 15 years of follow-up in the SHARE (Survey of Health, Aging and Retirement in Europe) study.

Methods

Depressive symptoms were defined using the EURO-D, with a score ≥4 indicative of depression. Incident dementia was ascertained using self-reported data and caregivers' information, cognitive impairment using objective cognitive tests. Cox regression analysis, adjusted for 10 baseline confounders, was run and hazard ratios (HRs), with their 95% confidence intervals, were estimated.

Results

In total 22,789 participants were included in the present analysis (mean age 64.2 years) and were predominantly female. The prevalence of depression at baseline was 24.9%. Over 15 years of follow-up, the onset of dementia occurred a median 2 years earlier in people with depression compared to those without. Depression at the baseline significantly increased the risk of dementia in the overall sample (HR = 1.74; 95% CI: 1.54–1.95) and the risk of cognitive impairment (HR = 1.15; 95% CI: 1.06–1.25). For dementia, the association was stronger in people less than 60 years (HR = 2.07; 95% CI: 1.42–3.02) than in participants aged ≥80 years (HR = 1.47; 95% CI: 1.14–1.91). A similar trend was observed for cognitive impairment. Among the single items of the EURO-D, loss of concentration was the strongest individual variable predicting the onset of dementia.

Conclusions

Depression increased the risk of dementia and cognitive impairment, particularly in younger adults, whereas loss of concentration was the strongest individual predicting variable of dementia. These findings demonstrate the need for early detection of depression for preventing future cognitive worsening.

查看原文本刊更多论文

抑郁症与痴呆症之间的关系：份额研究的纵向发现。

背景：抑郁症与痴呆症之间的关系尚不明确，尤其是抑郁症作为痴呆症前的潜在风险因素。因此，我们的目的是验证在欧洲健康、老龄和退休调查（SHARE）研究中，基线存在抑郁症是否会增加 15 年随访期间痴呆症和认知障碍的风险：抑郁症状采用EURO-D界定，得分≥4分表示抑郁。通过自我报告数据和护理人员信息确定痴呆症发病情况，通过客观认知测试确定认知障碍情况。在对10个基线混杂因素进行调整后，进行了Cox回归分析，并估算出了危险比（HRs）及其95%置信区间：本次分析共纳入 22789 名参与者（平均年龄 64.2 岁），以女性为主。基线抑郁症患病率为 24.9%。在15年的随访中，抑郁症患者与非抑郁症患者相比，痴呆症的发病时间中位数提前了2年。在总体样本中，基线抑郁会明显增加痴呆症的风险（HR = 1.74；95% CI：1.54-1.95）和认知障碍的风险（HR = 1.15；95% CI：1.06-1.25）。就痴呆症而言，60 岁以下人群（HR = 2.07；95% CI：1.42-3.02）比年龄≥80 岁的参与者（HR = 1.47；95% CI：1.14-1.91）更容易患痴呆症。在认知障碍方面也观察到类似的趋势。在EURO-D的单个项目中，注意力不集中是预测痴呆症发病的最强个体变量：结论：抑郁症会增加痴呆症和认知障碍的风险，尤其是在年轻人中，而注意力不集中则是预测痴呆症的最强个体变量。这些发现表明，有必要及早发现抑郁症，以防止未来认知功能的恶化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Geriatric Psychiatry 医学-精神病学

CiteScore

6.10

自引率

2.50%

发文量

168

审稿时长

4-8 weeks

期刊介绍： The rapidly increasing world population of aged people has led to a growing need to focus attention on the problems of mental disorder in late life. The aim of the Journal is to communicate the results of original research in the causes, treatment and care of all forms of mental disorder which affect the elderly. The Journal is of interest to psychiatrists, psychologists, social scientists, nurses and others engaged in therapeutic professions, together with general neurobiological researchers. The Journal provides an international perspective on the important issue of geriatric psychiatry, and contributions are published from countries throughout the world. Topics covered include epidemiology of mental disorders in old age, clinical aetiological research, post-mortem pathological and neurochemical studies, treatment trials and evaluation of geriatric psychiatry services.