The Role of DNA Methylation in Gastrointestinal Disease: An Expanded Review of Malignant and Nonmalignant Gastrointestinal Diseases.

IF 25.7 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterology Pub Date : 2025-02-01 Epub Date: 2024-07-04 DOI:10.1053/j.gastro.2024.07.001

Andrew Kalra, Stephen J Meltzer

引用次数: 0

Abstract

Esophageal, colorectal, pancreatic, hepatocellular, and gastric cancer together impact millions of patients worldwide each year, with high overall mortality rates, and are increasing in incidence. Additionally, premalignant gastrointestinal diseases, such as Barrett's esophagus and inflammatory bowel disease, are also increasing in incidence. However, involvement of aberrant DNA methylation in these diseases is incompletely understood, especially given recent research advancements in this field. Here, we review knowledge of this epigenetic mechanism in gastrointestinal preneoplasia and neoplasia, considering mechanisms of action, genetic and environmental factors, and 5'-C-phosphate-G-3' island methylator phenotype. We also highlight developments in translational research, focusing on genomic-wide data, methylation-based biomarkers and diagnostic tests, machine learning, and therapeutic epigenetic strategies.

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DNA 甲基化在胃肠道疾病中的作用：恶性和非恶性胃肠道疾病扩展综述》。

食道癌、结直肠癌、胰腺癌、肝癌和胃癌每年影响着全球数百万患者，总体死亡率很高，而且发病率还在不断上升。此外，巴雷特食管和炎症性肠病等恶性胃肠道疾病的发病率也在上升。然而，人们对 DNA 甲基化异常与这些疾病的关系尚不完全了解，尤其是考虑到该领域最近的研究进展。在此，我们回顾了胃肠道肿瘤前病变和肿瘤中这种表观遗传机制的知识，考虑了作用机制、遗传和环境因素以及 CpG 岛甲基化表型。我们还强调了转化研究的发展，重点关注全基因组数据库数据、基于甲基化的生物标记物和诊断测试、机器学习和表观遗传学治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterology 医学-胃肠肝病学

CiteScore

45.60

自引率

2.40%

发文量

4366

审稿时长

26 days

期刊介绍： Gastroenterology is the most prominent journal in the field of gastrointestinal disease. It is the flagship journal of the American Gastroenterological Association and delivers authoritative coverage of clinical, translational, and basic studies of all aspects of the digestive system, including the liver and pancreas, as well as nutrition. Some regular features of Gastroenterology include original research studies by leading authorities, comprehensive reviews and perspectives on important topics in adult and pediatric gastroenterology and hepatology. The journal also includes features such as editorials, correspondence, and commentaries, as well as special sections like "Mentoring, Education and Training Corner," "Diversity, Equity and Inclusion in GI," "Gastro Digest," "Gastro Curbside Consult," and "Gastro Grand Rounds." Gastroenterology also provides digital media materials such as videos and "GI Rapid Reel" animations. It is abstracted and indexed in various databases including Scopus, Biological Abstracts, Current Contents, Embase, Nutrition Abstracts, Chemical Abstracts, Current Awareness in Biological Sciences, PubMed/Medline, and the Science Citation Index.