Frequency of Euroglyphus maynei sensitization in respiratory allergies: a real-life study with bioinformatic analysis and geographical exploration of allergen prevalence.
Stefano Palazzo, Alessandro Cinquantasei, Concetta De Chirico, Marco Zurlo, Vincenzo Aresta, Nada Chaoul, Marcello Albanesi
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Abstract
Background: Dermatophagoides pteronyssinus and Dermatophagoides farinae belong to the family Pyroglyphidae (subfamily: "Dermatophagoidinae") and have the respective allergenic proteins of Der p1, Der p2, and Der p23 and Der f1 and Der f2. Euroglyphus maynei, belongs to the family Pyroglyphidae (subfamily: "Pyroglyphinae") and its main allergenic protein is Eur m1, a source of sensitization. Sensitization to D. pteronyssinus and D. farinae is assessed through skin tests, while sensitization to E. maynei is assessed less frequently.
Objective: This experimental work aims to analyze the prevalence of sensitization to E. maynei in patients with respiratory allergies treated at M. Albanesi Allergy and Immunology Unit in Bari, Italy, and the sequence homology of major allergenic proteins of E. maynei with D. farinae and D. pteronyssinus was analyzed.
Methods: In this real-life study, 65 patients were enrolled. In particular, patients with respiratory allergy were subjected to skin prick tests for common respiratory allergens, including Euroglyphus maynei. The sequence homology analysis was performed between the major allergenic proteins of E. maynei and those of D. pteronyssinus and D. farinae.
Results: Sensitization to E. maynei accounts for 41.5% of patients. All patients with E. maynei sensitization had concomitant sensitization to D. farinae and D. pteronyssinus. The analysis of sequence homology of Der p1 and Der f1 proteins with the sequence of Eur m1 protein demonstrated an identity of 84.4% and 86%, respectively.
Conclusions: Nearly 50% of house dust mites-sensitized patients have a concomitant sensitization to E. maynei. The cross-sensitization could be due to Der f1, Der p1, and Eur m1 similarity.
背景：Dermatophagoides pteronyssinus 和 Dermatophagoides farinae 属于脓疱疹科（亚科："Dermatophagoidinae"），其过敏蛋白分别为 Der p1、Der p2 和 Der p23 以及 Der f1 和 Der f2。Euroglyphus maynei 属于蚜蝇科（亚科："蚜蝇属"），其主要致敏蛋白是 Eur m1，是致敏源。对 D. pteronyssinus 和 D. farinae 的过敏性通过皮试进行评估，而对 E. maynei 的过敏性则较少评估：本实验旨在分析在意大利巴里 M. Albanesi 过敏和免疫科接受治疗的呼吸道过敏症患者对 E. maynei 的致敏率，并分析 E. maynei 与 D. farinae 和 D. pteronyssinus 的主要致敏蛋白的序列同源性：在这项实际研究中，共招募了 65 名患者。方法：在这项真实的研究中，共招募了 65 名患者，尤其是呼吸道过敏患者，对常见的呼吸道过敏原（包括麦地那龙线虫）进行皮肤点刺试验。对E. maynei的主要致敏蛋白与D. pteronyssinus和D. farinae的主要致敏蛋白进行了序列同源性分析：结果：41.5%的患者对E. maynei过敏。所有对E. maynei过敏的患者都同时对D. farinae和D. pteronyssinus过敏。Der p1和Der f1蛋白与Eur m1蛋白序列的同源性分析表明，两者的同源性分别为84.4%和86%：结论：近50%对屋尘螨过敏的患者同时对E.maynei过敏。这种交叉致敏可能是由于 Der f1、Der p1 和 Eur m1 的相似性造成的。
期刊介绍：
Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.
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