Liposomes and niosomes production by a supercritical CO2 assisted process for topical applications: A comparative study

IF 3.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids Pub Date : 2024-06-26 DOI:10.1016/j.supflu.2024.106342

Lucia Baldino, Domenico Riccardi, Ernesto Reverchon

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Abstract

A supercritical CO₂ assisted process was used to perform a comparative study between liposomes and niosomes. Process operating conditions were fixed at 100 bar and 40 °C, and the produced vesicles were characterized in terms of mean diameter, size distribution, ζ-potential, and stability over time. Mean diameters of liposomes and niosomes were similar (130 ± 37 nm for liposomes and 141 ± 36 nm for niosomes) and both systems were stable after 1 month from production. Ascorbic acid (AA) was loaded in both kinds of formulation. AA encapsulation efficiency was equal to 92 % and 99 % for liposomes and niosomes, respectively, and DPPH-activity was larger than 90 % in both vesicular systems. Drug release tests revealed that AA was released in 120 min and 240 min from liposomes and niosomes, respectively, due to a different compactness of the vesicle bilayer.

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通过超临界二氧化碳辅助工艺生产局部应用的脂质体和niosomes：比较研究

利用超临界二氧化碳辅助工艺对脂质体和niosomes进行了比较研究。工艺操作条件固定为 100 巴和 40 °C，生产出的囊泡在平均直径、大小分布、ζ电位和随时间变化的稳定性方面都有特征。脂质体和niosomes的平均直径相似（脂质体为130 ± 37 nm，niosomes为141 ± 36 nm），两种体系在生产1个月后都很稳定。两种制剂都含有抗坏血酸（AA）。脂质体和niosomes的AA包封效率分别为92%和99%，两种囊泡体系的DPPH活性均大于90%。药物释放测试表明，由于囊泡双分子层的紧密度不同，AA分别在120分钟和240分钟内从脂质体和niosomes中释放出来。

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来源期刊

Journal of Supercritical Fluids 工程技术-工程：化工

CiteScore

7.60

自引率

10.30%

发文量

236

审稿时长

56 days

期刊介绍： The Journal of Supercritical Fluids is an international journal devoted to the fundamental and applied aspects of supercritical fluids and processes. Its aim is to provide a focused platform for academic and industrial researchers to report their findings and to have ready access to the advances in this rapidly growing field. Its coverage is multidisciplinary and includes both basic and applied topics. Thermodynamics and phase equilibria, reaction kinetics and rate processes, thermal and transport properties, and all topics related to processing such as separations (extraction, fractionation, purification, chromatography) nucleation and impregnation are within the scope. Accounts of specific engineering applications such as those encountered in food, fuel, natural products, minerals, pharmaceuticals and polymer industries are included. Topics related to high pressure equipment design, analytical techniques, sensors, and process control methodologies are also within the scope of the journal.